From the Research
CD34+ stem cells are typically 6-10 micrometers in diameter, with a mean electronic volume of 407 microm(3), corresponding to a cell diameter of approximately 9.25 micrometers, as reported in the study by 1. These hematopoietic stem cells are relatively small compared to many other cell types in the human body, similar in size to lymphocytes. Their small size is characteristic of undifferentiated cells, as they have not yet developed the specialized structures found in mature blood cells. CD34+ stem cells are identified by the presence of the CD34 surface glycoprotein marker, which is used to isolate these cells for research and clinical applications such as bone marrow transplantation. The size of these cells is important for their function, allowing them to navigate through blood vessels and bone marrow spaces as they circulate and home to appropriate niches. Their compact size also reflects their primitive state, with a high nuclear-to-cytoplasmic ratio typical of stem cells that have not yet committed to specific lineages.
Some studies, such as 2 and 3, focus on the enumeration and analysis of CD34+ stem cells, but do not provide specific information on their size. However, the study by 1 provides direct measurements of the electronic cell volume of CD34+ stem cells, making it the most relevant and reliable source for determining their size. Other studies, such as 4 and 5, discuss the immunophenotype and frequency of CD34+ cells, but do not provide information on their size. Therefore, the size of CD34+ stem cells can be confidently determined based on the findings of the study by 1.
Key points to consider when evaluating the size of CD34+ stem cells include:
- The mean electronic volume of CD34+ cells is 407 microm(3) 1
- The corresponding cell diameter is approximately 9.25 micrometers 1
- CD34+ stem cells are relatively small compared to other cell types in the human body
- Their small size is characteristic of undifferentiated cells and reflects their primitive state.