From the Guidelines
You should not adjust your Adderall XR dosage when taking omeprazole without consulting your healthcare provider first, as the interaction between these medications can potentially alter the absorption and effectiveness of Adderall XR 1. When considering dosage adjustments, it's essential to follow a consistent titration schedule, increasing the dose in weekly increments of 2.5 to 5 mg for DEX/AMP, as recommended for stimulant medications 1. Key considerations for managing Adderall XR dosage include:
- Using a consistent titration schedule to achieve symptom control
- Systematically assessing treatment-related side effects, such as insomnia, anorexia, headaches, and weight loss
- Providing a schedule for initial titration and monitoring, with weekly contact during the titration phase
- Regularly evaluating target symptoms of ADHD, using parent and teacher rating scales, and obtaining self-ratings from adolescents and adults If you notice any changes in Adderall's effects after starting omeprazole, such as decreased effectiveness or increased side effects, contact your doctor immediately, as they may need to monitor your response and adjust your medication accordingly 1. It's crucial to inform all healthcare providers about all medications being taken to prevent potential drug interactions and ensure careful medical supervision, especially with stimulant medications like Adderall XR 1.
From the Research
Dosage Adjustment of Adderall XR with Omeprazole
There are no research papers to assist in answering this question, as the provided studies focus on the effectiveness and dosage of omeprazole in treating various conditions, but do not mention Adderall XR or its interaction with omeprazole.
Key Findings on Omeprazole Dosage
- The recommended starting dose of omeprazole is 60 mg/day, but it can be reduced to 20 mg once or twice a day in some patients 2
- Omeprazole 20 to 40 mg/day is effective in treating duodenal ulcer, gastric ulcer, and reflux oesophagitis 3
- The dosage of omeprazole should be adjusted according to individual response, and relatively low dosages of 10 to 40 mg/day may be sufficient in some patients 3
- Divided dosing of omeprazole 20 mg b.i.d. provides superior gastric acid suppression compared to once a day regimen of omeprazole 40 mg in most individuals 4
- Usual omeprazole dosages are 10 to 40 mg/day for adults and 10 to 20 mg/day for children 5
Interaction with Other Medications
- Omeprazole can potentially interact with the hepatic microsomal cytochrome P-450 enzymes, and may decrease the clearance of diazepam and phenytoin 6