Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 28, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for 33-year-old Female with Cystic Lesions

Single Most Likely Diagnosis

  • Hidradenitis Suppurativa (HS): This condition is characterized by recurrent, painful, and inflamed cysts and nodules, often in areas prone to apocrine sweat gland concentration like the neck, face, and ears. The description of cystic lesions that are itchy, painful, and open with yellow discharge aligns closely with HS, especially given the long history of lesions.

Other Likely Diagnoses

  • Acne Vulgaris: Although more common in younger populations, acne can persist into adulthood and may present with cystic lesions, especially if severe. The presence of itch and pain, along with the potential for discharge, could fit a severe acne picture.
  • Furuncles/Carbuncles: These are infections of the hair follicle that can present as painful, pus-filled lesions. They can occur anywhere on the body, including the face, neck, and ears, and could match the description given, especially if the lesions are opening and draining.
  • Keratosis Pilaris: While typically less severe, keratosis pilaris can cause small, rough bumps on the skin that might become inflamed or infected, leading to symptoms similar to those described.

Do Not Miss Diagnoses

  • Squamous Cell Carcinoma: Although less likely, any long-standing or changing skin lesion should prompt consideration of skin cancer. Squamous cell carcinoma can present as a firm, growing bump that may ulcerate and bleed, and while the description doesn't perfectly match, the potential severity warrants consideration.
  • Lymphoma (Cutaneous T-Cell Lymphoma): Certain types of lymphoma can present with skin lesions that are itchy, painful, and may resemble other dermatological conditions. Given the potential for severe outcomes, it's crucial not to miss this diagnosis.

Rare Diagnoses

  • Steatocystoma Multiplex: A rare condition characterized by multiple, benign cysts that can appear on the face, neck, and other areas. These cysts can become inflamed and rupture, potentially matching the description provided.
  • Erythema Induratum: A rare condition associated with tuberculosis, characterized by recurring nodules and ulcers, typically on the calves but potentially elsewhere, including the face and neck. The symptoms could align with those described, especially in a patient with a history of tuberculosis exposure.

Related Questions

What is the management approach for individuals with Turner syndrome suspected of having panhypopituitarism?
Can a patient with a colon infection who received an intravenous (IV) dose of Flagyl (metronidazole) at 12am be started on an oral dose at 5pm?
Is there a connection between Turner syndrome and panhypopituitarism?
What medications are used to treat post dural puncture headache?
What are the initial steps in managing emergency medicine situations?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.

Ask Question