Angioedema: This condition is characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues. It can be caused by allergic reactions, medications, or inherited conditions. The swelling of the tongue and sore throat can be symptoms of angioedema, especially if the patient has a history of allergies or recent exposure to potential allergens.

Tonsillitis: Inflammation of the tonsils can cause a sore throat and, in severe cases, swelling that might affect the tongue or the surrounding areas.
Mononucleosis (Mono): Caused by the Epstein-Barr virus, mono can lead to sore throat and swollen lymph nodes, which might indirectly cause discomfort or swelling in the tongue area.
Oral Infections: Dental infections, such as abscesses, or other oral infections can cause swelling and pain in the mouth, including the tongue, and a sore throat.

Epiglottitis: Although rare, epiglottitis is a potentially life-threatening condition that causes inflammation of the epiglottis, which can lead to severe swelling and obstruction of the airway. Symptoms can include a sore throat and difficulty swallowing, which might be associated with tongue swelling in severe cases.
Anaphylaxis: A severe, life-threatening allergic reaction that can cause swelling of the tongue, throat, and face, leading to airway obstruction. It requires immediate medical attention.

Amyloidosis: A condition characterized by the deposition of amyloid proteins in various tissues, which can lead to swelling and enlargement of the tongue (macroglossia) and potentially cause a sore throat due to the mechanical effects of the enlarged tongue.
Sarcoidosis: A disease that can affect multiple parts of the body, including the lymph nodes, lungs, and less commonly, the tongue and throat, causing swelling and discomfort.
Oral Cancer: Although rare, cancers of the tongue or throat can cause swelling, pain, and soreness in these areas, especially if the cancer is advanced.