What are the recommendations for reevaluating sepsis under the Merit-based Incentive Payment System (MIPS)?

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Last updated: October 29, 2025View editorial policy

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MIPS Sepsis Reevaluation Recommendations

For patients with suspected sepsis, the National Early Warning Score 2 (NEWS2) should be recalculated at specific intervals based on risk stratification: every 30 minutes for high-risk patients, hourly for moderate-risk patients, every 4-6 hours for low-risk patients, and according to local protocol for very low-risk patients. 1

Risk Stratification Using NEWS2

NEWS2 is the recommended tool for evaluating sepsis risk and determining reevaluation frequency:

  • High risk (NEWS2 score ≥7): Reevaluate every 30 minutes 1
  • Moderate risk (NEWS2 score 5-6): Reevaluate every hour 1
  • Low risk (NEWS2 score 1-4): Reevaluate every 4-6 hours 1
  • Very low risk (NEWS2 score 0): Follow local protocol 1

Key Components of Sepsis Reevaluation

Clinical Assessment

  • Reassess for signs of deterioration or improvement since previous evaluation 1
  • Consider risk as higher than suggested by NEWS2 if condition is deteriorating or has not improved since previous assessment 1
  • Evaluate for specific signs indicating high risk regardless of NEWS2 score:
    • Mottled or ashen appearance 1
    • Non-blanching petechial or purpuric rash 1
    • Cyanosis of skin, lips, or tongue 1

Antimicrobial Management

  • Reassess effectiveness of antimicrobial regimen regularly 1
  • Review antimicrobial choice when source of infection is confirmed or microbiological results become available 1
  • Consider narrowing antibiotic spectrum based on culture results within one hour of calculating NEWS2 score 1
  • Evaluate for treatment failure if worsening or ongoing organ dysfunction and persistence of infectious signs for more than 48-72 hours 1

Special Considerations

Antibiotic Administration Timing Based on Risk

  • High-risk patients: Administer antibiotics within 1 hour 1
  • Moderate-risk patients: Administer antibiotics within 3 hours 1
  • Low-risk patients: Administer antibiotics within 6 hours 1

Performance Improvement

  • Implement sepsis performance improvement programs focused on earlier recognition through formal screening 1
  • Monitor compliance with sepsis bundles as this has been associated with decreased mortality 1
  • Utilize sepsis screening tools as they are associated with earlier treatment and decreased mortality 1

Common Pitfalls in Sepsis Reevaluation

  • Failure to interpret NEWS2 in context: Always consider the patient's underlying physiology and comorbidities when interpreting scores 1
  • Missing single parameter significance: A score of 3 in any single parameter may indicate increased risk from sepsis even if total score is low 1
  • Overlooking deterioration: Consider risk as higher than suggested by NEWS2 if condition is deteriorating despite interventions 1
  • Inadequate source control: Regular assessment is essential to promptly recognize inadequate source control 1
  • Delayed antibiotic adjustment: Failure to narrow antibiotic spectrum when culture results become available 1

Documentation Requirements for MIPS

  • Document time of sepsis recognition 1
  • Record all NEWS2 scores with timestamps 1
  • Document reassessments at appropriate intervals based on risk stratification 1
  • Record antibiotic administration times and any adjustments to therapy 1
  • Document response to interventions 1

By following these evidence-based recommendations for sepsis reevaluation, clinicians can optimize patient outcomes while meeting MIPS requirements for sepsis management.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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