Differential Diagnosis for Left Leg Swelling, Warmth, and Fatigue

Single Most Likely Diagnosis

• Deep Vein Thrombosis (DVT): This condition is characterized by the formation of a blood clot in a deep vein, typically in the legs. Symptoms include swelling, warmth, and fatigue in the affected limb, which aligns with the patient's presentation. DVT is a common cause of leg swelling and can lead to serious complications like pulmonary embolism if not treated promptly.

Other Likely Diagnoses

• Cellulitis: A bacterial skin infection that can cause swelling, redness, warmth, and fatigue. It's a common condition that can be treated with antibiotics but needs to be differentiated from DVT due to its different management approach.
• Lymphedema: Swelling caused by impaired lymph drainage, which can lead to chronic swelling and fatigue. While it doesn't typically cause warmth, it's a consideration in chronic cases.
• Varicose Veins: Enlarged veins that can cause swelling, warmth, and fatigue due to poor blood circulation. They are common and can be a source of discomfort and cosmetic concern.

Do Not Miss Diagnoses

• Pulmonary Embolism: Although it primarily presents with respiratory symptoms, a pulmonary embolism can occasionally manifest with leg symptoms if it's related to a DVT that has broken loose. Missing this diagnosis can be fatal.
• Compartment Syndrome: A condition where increased pressure within a muscle compartment leads to inadequate blood supply to the tissues inside the compartment. It's an emergency that requires immediate surgical intervention to prevent permanent damage.
• Septic Thrombophlebitis: An infection of the veins that can cause fever, chills, and swelling. It's less common but can be life-threatening if not treated with appropriate antibiotics.

Rare Diagnoses

• Klippel-Trenaunay Syndrome: A rare congenital condition characterized by abnormal development of blood vessels, soft tissue, and bone, leading to swelling, varicose veins, and other symptoms.
• Lipedema: A chronic condition characterized by the abnormal growth of fat cells in the legs, leading to swelling and discomfort. It's often mistaken for lymphedema but has distinct characteristics.
• Erythromelalgia: A disorder that causes burning pain, heat, and redness in the hands and feet, which can sometimes be confused with other conditions causing warmth and swelling.