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Last updated: October 29, 2025View editorial policy

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Differential Diagnosis for Chronic Phlegm in Throat

Single Most Likely Diagnosis

  • Chronic Postnasal Drip: This condition, often due to allergies or a deviated septum, leads to the constant dripping of mucus from the back of the nose into the throat, causing a sensation of chronic phlegm.

Other Likely Diagnoses

  • Gastroesophageal Reflux Disease (GERD): Stomach acid flowing back into the esophagus can irritate the throat, leading to increased mucus production and the sensation of phlegm.
  • Chronic Bronchitis: A type of COPD, chronic bronchitis involves inflammation of the bronchial tubes, leading to a persistent cough and mucus production.
  • Allergic Rhinitis: Allergies can cause nasal congestion and increased mucus production, which can lead to a sensation of phlegm in the throat.
  • Sinusitis: Inflammation or infection of the sinuses can cause increased mucus production, which may drain into the throat.

Do Not Miss Diagnoses

  • Lung Cancer: Although less common, lung cancer can cause chronic cough and mucus production. It's crucial to rule out this potentially life-threatening condition.
  • Tuberculosis (TB): A bacterial infection that primarily affects the lungs, TB can cause chronic cough, mucus production, and other systemic symptoms.
  • Pneumonia: Especially in vulnerable populations, pneumonia can present with chronic cough and phlegm production.

Rare Diagnoses

  • Cystic Fibrosis: A genetic disorder that leads to the production of thick, sticky mucus, which can cause respiratory and digestive problems.
  • Primary Ciliary Dyskinesia: A rare genetic disorder affecting the cilia in the respiratory tract, leading to chronic respiratory infections and mucus accumulation.
  • Vocal Cord Dysfunction: Abnormal movement of the vocal cords can cause symptoms similar to asthma, including chronic cough and sensation of phlegm.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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