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Last updated: October 29, 2025View editorial policy

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Differential Diagnosis for Stye with Eye Redness and Drainage

  • Single most likely diagnosis
    • Hordeolum (Stye): This is the most likely diagnosis given the presentation of a stye, which is a localized infection or inflammation of the eyelid margin involving hair follicles of the eyelashes or meibomian glands. The symptoms of eye redness and drainage are consistent with this condition.
  • Other Likely diagnoses
    • Blepharitis: An inflammation of the eyelids that can cause redness, itching, and drainage. It often accompanies or precedes a stye and can share similar symptoms.
    • Conjunctivitis: An infection or inflammation of the conjunctiva, which can cause eye redness and discharge. It can be viral, bacterial, or allergic in nature.
    • Dacryocystitis: An infection of the lacrimal sac, which can cause eye redness, swelling, and discharge, especially if there's an obstruction in the tear drainage system.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Orbital Cellulitis: A serious infection of the tissues surrounding the eye, which can cause redness, swelling, and discharge, but also proptosis, vision changes, and severe pain. It requires prompt medical attention.
    • Endophthalmitis: A severe inflammation of the interior of the eye, usually caused by infection. It's a medical emergency that can result in vision loss if not treated promptly.
  • Rare diagnoses
    • Keratitis: An inflammation of the cornea, which can be caused by infection or injury. While it can cause eye redness and pain, it's less commonly associated with a stye.
    • Angioedema: A rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues. It can cause significant eyelid swelling and, occasionally, redness and discomfort, but it's less likely to present with drainage.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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