Trigeminal Neuralgia: This condition is characterized by sudden, severe, and stabbing pain typically around the eyes, lips, and nose due to irritation of the trigeminal nerve. Cheek twitching and decreased face sensation can be associated symptoms. The headache could be part of the neuralgic pain or a separate entity.

Multiple Sclerosis (MS): MS can cause a wide range of neurological symptoms, including facial numbness, twitching, and headaches. The optic neuritis associated with MS could also lead to pain.
Stroke or Transient Ischemic Attack (TIA): Although less common, a stroke or TIA affecting the brainstem or the areas responsible for facial sensation could present with these symptoms.
Migraine: Certain types of migraines, especially those with aura, can cause neurological symptoms including facial numbness and twitching, along with headache.

Brain Tumor: A tumor pressing on the trigeminal nerve or other parts of the brain could cause these symptoms. It's crucial to rule out this possibility due to its severe implications.
Lyme Disease: Neurological manifestations of Lyme disease can include facial palsy and numbness, along with headache.
Sarcoidosis: This autoimmune disease can affect the nervous system, causing a variety of symptoms including facial numbness and weakness.

Hemifacial Spasm: A rare neurological disorder characterized by irregular, involuntary muscle contractions on one side of the face, which could be mistaken for twitching.
Neurosyphilis: A complication of untreated syphilis that can cause a wide range of neurological symptoms, including facial numbness and headache.
Mitochondrial Myopathies: Rare genetic disorders that affect the mitochondria and can cause a variety of neurological symptoms, including muscle twitching and sensory abnormalities.