From the Guidelines
Alfuzosin does not have a significant impact on Prostate-Specific Antigen (PSA) blood test results, as there is no direct evidence in the provided guideline to suggest that it affects PSA levels. The guideline primarily focuses on the use of alpha-1 adrenergic receptor blockers, including alfuzosin, for the treatment of Lower Urinary Tract Symptoms (LUTS) secondary to Benign Prostatic Hyperplasia (BPH) [ 1 ]. The guideline discusses the efficacy and safety of alfuzosin, doxazosin, tamsulosin, and terazosin in relieving symptoms of BPH, but it does not mention any effect on PSA levels [ 1 ]. Some key points to consider when using alfuzosin for BPH treatment include:
- Alfuzosin is an appropriate treatment option for patients with LUTS secondary to BPH [ 1 ]
- The primary adverse events reported with alpha-blocker therapy are orthostatic hypotension, dizziness, tiredness, ejaculatory problems, and nasal congestion [ 1 ]
- Patients with hypertension may require separate management of their hypertension when using alpha blockers [ 1 ] It is essential to note that the provided guideline does not address the impact of alfuzosin on PSA levels, and therefore, no recommendation can be made regarding its effect on PSA blood test results.
From the Research
Alfuzosin and PSA Blood Test Results
- The study 2 evaluated the efficacy of alfuzosin in patients with prostatism and found that there were no significant differences in total and free PSA levels before and after treatment.
- This suggests that alfuzosin may not impact Prostate-Specific Antigen (PSA) blood test results.
- Further studies 3, 4, 5, 6 focused on the efficacy and safety of alfuzosin in treating benign prostatic hyperplasia, but did not specifically address the impact of alfuzosin on PSA blood test results.
Key Findings
- Alfuzosin is a selective alpha-1 adrenergic receptor blocker that reduces the tone of the lower urinary tract smooth muscle, thereby reducing symptoms associated with benign prostatic hyperplasia 3.
- The treatment with alfuzosin improves lower urinary tract symptoms, quality of life, and may even improve sexual function in men with concomitant erectile and/or ejaculatory dysfunction 5, 6.
- Alfuzosin is well tolerated, with the most common adverse event related to vasodilatation being dizziness/postural dizziness, and ejactulatory disorders being uncommon 4, 6.