Stiolto Respimat Packaging Information
Stiolto Respimat (tiotropium/olodaterol) comes packaged as a hand-held, pocket-sized oral inhalation device that delivers medication through a slow-moving aerosol cloud generated from a metered volume of drug solution. 1
Packaging Components and Specifications
- Stiolto Respimat consists of a sterile aqueous solution of tiotropium bromide and olodaterol hydrochloride filled into a 4.5 mL plastic container crimped into an aluminum cylinder (Stiolto Respimat cartridge) 1
- The cartridge is designed for use only with the Stiolto Respimat inhaler device 1
- The Stiolto Respimat inhaler has a distinctive light green-colored cap for identification 1
- Each cartridge contains 4 grams of sterile aqueous solution and delivers the labeled number of metered actuations after preparation for use 1
Medication Delivery
- Each dose (defined as two actuations) from the Stiolto Respimat inhaler delivers 5 mcg tiotropium (equivalent to 6.247 mcg tiotropium bromide monohydrate) and 5 mcg olodaterol (equivalent to 5.473 mcg olodaterol hydrochloride) 1
- The medication is delivered in 22.1 mcL of solution from the mouthpiece 1
- The actual amount of drug delivered to the lungs may depend on patient factors, such as coordination between actuation and inspiration 1
Formulation Details
- The solution contains excipients including benzalkonium chloride, edetate disodium, hydrochloric acid, and water for injection 1
- The combination provides both a long-acting muscarinic antagonist (tiotropium) and a long-acting beta2-adrenergic agonist (olodaterol) in a single device 2, 3
Clinical Considerations
- The Respimat soft-mist inhaler technology provides a slow-moving mist that allows for effective drug delivery 3
- The once-daily dosing regimen offers convenience for patients compared to multiple daily dosing requirements of some other COPD medications 2, 4
- The duration of inspiration should be at least as long as the spray duration (1.5 seconds) for optimal medication delivery 1
Storage and Handling
- The inhaler with inserted cartridge should be used within 3 months of opening the foil pouch
- The device should be stored at room temperature and protected from freezing
This packaging design allows for convenient once-daily administration of dual bronchodilator therapy for COPD patients, with the benefits of both medications delivered through a single inhaler device 5, 6.