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Last updated: October 29, 2025View editorial policy

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Differential Diagnosis for a Round Nodule in the Breast that is Non-Mobile

  • Single Most Likely Diagnosis
    • Fibroadenoma: This is a common benign breast tumor, especially in younger women. They are often round, firm, and non-mobile, which matches the description provided.
  • Other Likely Diagnoses
    • Cyst: Breast cysts are fluid-filled sacs within the breast and can present as round nodules. They are usually mobile but can be non-mobile if they are large or if there is surrounding inflammation.
    • Lipoma: A benign tumor composed of fat tissue, which can feel like a round nodule in the breast. Lipomas are generally mobile, but their mobility can be limited by their size or location.
    • Hamartoma: A benign breast tumor that is a mix of glandular, fibrous, and fatty tissues. It can present as a round, non-mobile mass.
  • Do Not Miss Diagnoses
    • Breast Cancer (e.g., Invasive Ductal Carcinoma): Although less likely than benign conditions, breast cancer must always be considered, especially if the nodule is non-mobile and hard. Early detection is crucial for treatment and prognosis.
    • Phyllodes Tumor: These are rare tumors that can be benign, borderline, or malignant. They can grow quickly and may present as a large, non-mobile mass.
  • Rare Diagnoses
    • Pseudoangiomatous Stromal Hyperplasia (PASH): A rare benign condition that can mimic breast cancer on imaging. It can present as a non-mobile mass.
    • Granular Cell Tumor: A rare tumor that can occur in the breast, usually presenting as a firm, non-mobile mass.
    • Metastasis to the Breast: Although rare, metastases from other cancers (like lymphoma, melanoma, or ovarian cancer) can present as round, non-mobile nodules in the breast.

Each diagnosis has a brief justification based on the characteristics of the breast nodule described (round and non-mobile) and the typical presentations of these conditions. The categorization helps in prioritizing the most likely and critical diagnoses for further investigation and management.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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