What is the maximum duration a peripheral intravenous (IV) catheter can remain in place?

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Last updated: October 29, 2025View editorial policy

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Duration of Peripheral Intravenous Catheter Placement

In adults, peripheral intravenous catheters should be replaced every 72-96 hours to reduce the risk of phlebitis, while in pediatric patients, catheters can remain in place until IV therapy is completed unless complications occur. 1, 2

Adult Peripheral IV Catheter Replacement Guidelines

  • Replace short peripheral venous catheters in adults at least every 72-96 hours to reduce the risk of phlebitis 2
  • If venous access sites are limited and no signs of complications are present, peripheral catheters may remain in place longer, but require close monitoring of both the patient and insertion site 2
  • Clinically-indicated replacement (rather than routine replacement) has been shown to not increase phlebitis rates and may actually reduce phlebitis per 1000 catheter-days 3
  • The probability of a standard open-system PIVC lasting 96 hours without complications is approximately 80%, while closed-system PIVCs may safely remain in place for up to 144 hours 4

Pediatric Peripheral IV Catheter Guidelines

  • In pediatric patients, peripheral venous catheters should be left in place until IV therapy is completed, unless complications occur 2
  • Complications requiring immediate removal include signs of phlebitis (warmth, tenderness, erythema, palpable venous cord), infection, infiltration, or catheter malfunction 2, 5
  • Despite the longer dwell time permitted in pediatrics, daily evaluation of the catheter insertion site is still essential 5

Monitoring and Maintenance Requirements

  • Evaluate catheter insertion sites daily by palpation through the dressing to detect tenderness, and by visual inspection if a transparent dressing is used 2, 1
  • Remove peripheral venous catheters immediately if the patient develops signs of phlebitis, infection, or catheter malfunction 2, 5
  • Clean injection ports with 70% alcohol or an iodophor before accessing the system 2, 1
  • Cap all stopcocks when not in use to prevent contamination 2

Special Considerations

  • Use a midline catheter or PICC when IV therapy is expected to exceed 6 days 2
  • Catheters inserted under emergency conditions should be replaced within 48 hours 1
  • Designate trained personnel for insertion and maintenance of intravascular catheters to minimize complications 2, 1
  • Avoid steel needles for administration of fluids and medications that might cause tissue necrosis if extravasation occurs 5

Associated Component Replacement Schedule

  • Replace IV tubing and add-on devices no more frequently than every 72-96 hours 1
  • Replace tubing used for blood, blood products, or lipid emulsions within 24 hours of initiating the infusion 2, 1
  • Replace needleless components at least as frequently as the administration set (every 72-96 hours) 1

Common Pitfalls to Avoid

  • Do not delay removal of catheters when complications are suspected 5
  • Do not routinely apply prophylactic topical antimicrobial or antiseptic ointment to insertion sites of peripheral venous catheters 2, 5
  • Avoid placing new catheters in areas where previous complications have occurred 5
  • When using clinically-indicated replacement strategies rather than routine replacement, ensure staff are trained to recognize early signs of complications 6

References

Guideline

Frequency of IV Cannula Replacement

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Treatment for Blisters Around an Intravenous (IV) Line Site

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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