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Last updated: October 29, 2025View editorial policy

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Differential Diagnosis for Constipation and Bloating

Single Most Likely Diagnosis

  • Irritable Bowel Syndrome (IBS): This is the most common diagnosis for patients presenting with constipation and bloating, characterized by a combination of abdominal pain, bloating, and alteration in bowel habits without any mechanical, inflammatory, or biochemical abnormalities.

Other Likely Diagnoses

  • Functional Constipation: A condition where constipation occurs without an identifiable cause, often related to diet, lifestyle, or bowel habits.
  • Small Intestine Bacterial Overgrowth (SIBO): An excessive growth of bacteria in the small intestine, leading to bloating, gas, and changes in bowel movements.
  • Lactose Intolerance or Other Food Intolerances: Difficulty digesting certain foods can lead to bloating, gas, and constipation.
  • Hypothyroidism: An underactive thyroid gland can cause constipation among other symptoms.

Do Not Miss Diagnoses

  • Colorectal Cancer: Although less common, it's crucial to rule out colorectal cancer, especially in older adults or those with a family history, as it can present with changes in bowel habits and bloating.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause constipation, bloating, and other gastrointestinal symptoms, and require prompt diagnosis and treatment.
  • Intestinal Obstruction: A mechanical blockage of the intestine that can cause severe constipation, bloating, and abdominal pain, requiring immediate medical attention.
  • Gastrointestinal Motility Disorders: Conditions such as gastroparesis or intestinal pseudo-obstruction can lead to severe bloating and constipation due to impaired movement of food through the digestive tract.

Rare Diagnoses

  • Celiac Disease: An autoimmune reaction to gluten that can cause a variety of gastrointestinal symptoms, including bloating and constipation.
  • Gastroparesis: A condition where the stomach takes too long to empty its contents, which can lead to bloating, nausea, and changes in bowel habits.
  • Amyloidosis: A rare condition where abnormal proteins (amyloid) accumulate in various organs, including the gastrointestinal tract, potentially causing constipation and bloating.
  • Neurological Disorders: Certain neurological conditions, such as Parkinson's disease, can affect bowel movements and cause constipation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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