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Last updated: October 29, 2025View editorial policy

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Differential Diagnosis for Focal Medial Eye Redness

  • Single most likely diagnosis
    • Nasolacrimal duct obstruction: This condition is a common cause of medial eye redness, especially in infants, but can also occur in adults. It leads to inflammation and infection due to the blockage of tear drainage.
  • Other Likely diagnoses
    • Medial canthal tendonitis or abscess: Inflammation or infection of the medial canthal tendon can cause redness and swelling in the medial aspect of the eye.
    • Dacryocystitis: Infection or inflammation of the lacrimal sac can cause pain, redness, and swelling in the medial canthus.
    • Conjunctivochalasis: A condition where the conjunctiva becomes loose and folds over, potentially causing irritation and redness, particularly in the medial aspect of the eye.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Orbital cellulitis: Although less common, this condition is a serious infection of the tissues surrounding the eye and can cause significant morbidity if not promptly treated. It may present with medial eye redness among other symptoms.
    • Cavernous sinus thrombosis: A rare but potentially life-threatening condition that can arise from facial or orbital infections, including those causing medial eye redness.
  • Rare diagnoses
    • Sarcoidosis: A systemic disease that can cause uveitis and other ocular manifestations, including conjunctival nodules that might lead to focal redness.
    • Relapsing polychondritis: An autoimmune disorder that can affect the cartilage of the ears, nose, and eyes, potentially causing inflammation and redness in the medial canthus.
    • Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis): A systemic vasculitis that can affect various parts of the body, including the eyes, and cause a range of symptoms including redness and inflammation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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