Differential Diagnosis for Puckered Skin on Palm Opposite Thumb
- Single most likely diagnosis:
- Dupuytren's contracture: This condition is characterized by the thickening of the palmar fascia, leading to nodules and cord formation that can cause the skin to pucker, especially in the area opposite the thumb. It's a common condition, especially in older adults.
- Other Likely diagnoses:
- Palmar fasciitis: Inflammation of the palmar fascia can lead to thickening and puckering of the skin. This condition can be associated with various factors, including trauma, infection, or autoimmune diseases.
- Scar contracture: Previous injuries or surgeries on the palm can result in scar tissue formation, which may contract and cause puckering of the skin over time.
- Do Not Miss diagnoses:
- Malignant tumor (e.g., squamous cell carcinoma): Although rare, a malignant tumor on the palm can cause skin puckering. Early detection is crucial for effective treatment, making this a "do not miss" diagnosis.
- Infection (e.g., palmar abscess): A deep-seated infection on the palm can lead to skin puckering due to the accumulation of pus. Prompt recognition and treatment are essential to prevent serious complications.
- Rare diagnoses:
- Scleroderma: A chronic autoimmune disease that can cause thickening and hardening of the skin, potentially leading to puckering, especially in advanced cases.
- Kaposi's sarcoma: A rare type of cancer that can cause skin lesions, including on the palms, which might appear as puckered skin.
- Epidermoid cyst: A benign cyst that can form on the palm and cause localized skin puckering due to its growth.