Maximum Recommended Dose of Udenafil
The maximum recommended dose of udenafil for erectile dysfunction is 100 mg taken as needed, no more than once daily. 1, 2
Dosing Information
- Udenafil is a selective phosphodiesterase type 5 inhibitor (PDE5i) used for the treatment of erectile dysfunction 3
- Standard dosing options include:
- Timing considerations:
Efficacy and Safety
- Clinical trials have demonstrated significant improvements in erectile function compared to placebo at both 100 mg and 200 mg doses 2
- Most common adverse events are mild to moderate and include:
Important Considerations and Contraindications
- Like all PDE5 inhibitors, udenafil is absolutely contraindicated with nitrate medications due to risk of severe hypotension 3, 6
- Sexual stimulation is necessary for the medication to be effective 3
- Cardiovascular risk should be assessed before prescribing PDE5 inhibitors 6
- Patients who cannot perform exercise equivalent to walking 1 mile in 20 minutes or climbing 2 flights of stairs in 20 seconds should be referred to a cardiologist before treatment 6
Special Populations
- Use with caution in patients with mild to moderate hepatic or renal impairment, initially at lower doses 3
- Consider lower starting doses in elderly patients, similar to other PDE5 inhibitors 7
Treatment Approach
- Risk factor modification should be addressed alongside pharmacological treatment, including smoking cessation, weight loss, increasing physical activity, and avoiding excess alcohol consumption 6
- An adequate trial of a PDE5i is defined as at least 5 separate occasions at the maximum dose before reporting it as ineffective 6
- If udenafil fails, consider trying a different PDE5i before moving to second-line therapies 6