Recommended Dosage for Inj. Targocid (Teicoplanin)
For patients with normal renal function, the recommended dosage of Inj. Targocid (teicoplanin) is 30-60 mg/kg/day administered at 6-12 hour intervals, with a loading dose of 25-30 mg/kg for seriously ill patients. 1
Standard Dosing Regimen
- Initial loading dose: 6-12 mg/kg/dose IV q12h for three doses 1, 2
- Maintenance dose: 6-12 mg/kg/dose IV once daily 1, 2
- For seriously ill patients, a higher loading dose of 25-30 mg/kg is recommended 1, 2
Dosing Based on Infection Type
Skin and Soft-Tissue Infections (SSTI)
- For inpatient complicated SSTI: 6-12 mg/kg/dose IV q12h for three doses, then once daily 1
- Duration: 7-14 days 1, 2
Bacteremia
- Uncomplicated bacteremia: 6-12 mg/kg/dose IV q12h for three doses, then once daily 1
- Complicated bacteremia: 6-12 mg/kg/dose IV q12h for three to six doses, then 6-12 mg/kg/dose once daily 1
- Duration: 2 weeks for uncomplicated; 4-6 weeks for complicated bacteremia 1, 2
Endocarditis
- For serious infections such as endocarditis: 12 mg/kg twice daily loading dose is recommended 2
- Duration: 4-6 weeks for native valve endocarditis; 6 weeks for prosthetic valve endocarditis 2
Pneumonia
Pediatric Dosing
Monitoring Recommendations
- Routine monitoring of serum levels is not generally required for standard infections 2
- Monitoring is recommended for patients with S. aureus endocarditis, septic arthritis, major burns, intravenous drug users, or rapidly changing renal function 2
- Target trough concentration for severe infections such as endocarditis or septic arthritis: ≥20 mg/L 2, 3
- For most infections, trough levels of 10-15 μg/ml are considered optimal 4
Important Considerations
- A higher initial dose (800 mg followed by 400 mg for the next two days) has been shown to achieve therapeutic trough levels more reliably than standard dosing (400 mg followed by 200 mg) 4
- Increased doses of 600 mg daily (after loading) have been associated with improved serum levels without increased toxicity compared to 400 mg daily 5
- Teicoplanin has a long half-life (terminal half-life of 87 hours), allowing for once-daily administration after initial loading 6
- Teicoplanin has less potential than vancomycin to cause nephrotoxicity, especially when administered with an aminoglycoside 7
- Transition from parenteral to oral agents should be done cautiously and is not recommended for patients with complicated bacteremia 1, 2