What are the steps to troubleshoot an arterial line issue?

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Last updated: October 30, 2025View editorial policy

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Arterial Line Troubleshooting Protocol

When troubleshooting an arterial line issue, follow a systematic approach focusing on the flush solution, sampling technique, and system integrity to prevent dangerous errors that could lead to patient harm.

Initial Assessment

  • Verify that only sodium chloride 0.9% (with or without heparin) is being used as the arterial line flush solution to prevent dangerous sampling errors 1
  • Check that the flush solution bag is correctly labeled and positioned in a pressurizing device with a transparent front panel 1
  • Ensure the arterial line system is clearly identifiable with appropriate labels and color differentiation from other lines 1
  • Inspect the entire system for kinks, disconnections, air bubbles, or blood clots that may affect pressure readings or sampling 1

Waveform Issues

  • For dampened waveform:

    • Check for air bubbles in the line and flush thoroughly to remove them 1
    • Inspect for blood clots in the catheter and consider gentle aspiration followed by flushing 1
    • Verify the position of the catheter (may be against vessel wall) 2
    • Ensure the transducer is at the correct level (phlebostatic axis) 1
  • For absent waveform:

    • Confirm the arterial catheter is still in the artery and hasn't dislodged 2
    • Check all connections between catheter, tubing, and monitoring system 1
    • Ensure the pressure bag is inflated to 300 mmHg 1
    • Consider catheter occlusion or vessel spasm as potential causes 2

Blood Sampling Problems

  • When using an arterial line for blood sampling:

    • Use 'closed' arterial line sampling systems when possible to avoid sample contamination 1
    • With 'open' systems, minimize contamination by making the dead space volume between sampling port and arterial lumen as small as practicable 1
    • Ensure the syringe for dead space removal is readily distinguishable from the sampling syringe 1
    • Throughout sampling, prevent flush solution from entering the dead space, sample, or any three-way tap at the sampling site 1
  • For unexpected laboratory results:

    • Check for possible sample contamination with flush solution 3
    • If unexpected high glucose readings are obtained, verify the flush solution is not glucose-containing 3
    • Draw a confirmatory sample from an alternative site if contamination cannot be ruled out 3

Site-Related Issues

  • For site complications:
    • Assess for signs of infection, hematoma, or ischemia at the insertion site 2
    • Consider femoral placement if radial site is failing, as femoral arterial lines have significantly lower failure rates (5.4% vs 25.6-30.7%) 2
    • Monitor for signs of distal ischemia by checking capillary refill, color, and temperature of the extremity 2

System Maintenance

  • Independently double-check the flush infusion bag at least once during each nursing shift 1
  • Double-check the flush bag whenever nursing care of the patient is handed over 1
  • Include removal of the flush bag from its pressurizing device during checks 1
  • Ensure the system is properly zeroed and calibrated regularly 1

Common Pitfalls and Prevention

  • Never use glucose-containing solutions as arterial line flush, as even minimal contamination can lead to dangerous sampling errors 3, 1
  • Be cautious with sodium chloride 0.9% with glucose 5%, which can be easily confused with plain sodium chloride 0.9% 3
  • Watch for erratic or highly varying sequential test results, which should heighten suspicion of blood sample contamination 3
  • Be aware that even with proper technique using 5× dead space removal, significant glucose contamination can occur with glucose-containing flush solutions 3
  • Consider that radial arterial lines fail more frequently than femoral lines, with failures occurring sooner in radial sites 2

References

Guideline

Arterial Line System Setup and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Radial Arterial Lines Have a Higher Failure Rate than Femoral.

The western journal of emergency medicine, 2018

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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