What are the recommendations for using Bangpungtongsungsan (dried extract) 237.5mg?

Recommendations for Bangpungtongsung-san (Dried Extract) 237.5mg

Bangpungtongsung-san dried extract 237.5mg is recommended for digestive system complications including anorexia, diarrhea, and constipation, with syndrome differentiation being more effective than using Chinese patent medicines alone. 1

Therapeutic Applications

• Bangpungtongsung-san (BPTS) is a traditional herbal medicine widely used in Korea, Japan (Bofu-tsusho-san), and China (Fang feng tong sheng-san) primarily as an antiobesity prescription 2
• BPTS can be used for digestive system complications including anorexia, diarrhea, and constipation, with TCM decoctions based on syndrome differentiation showing more effectiveness than standardized Chinese patent medicines 1
• For abdominal fullness, anorexia, and nausea, BPTS contains herbs that have the effect of "regulating stomach and dissipating dampness" or "tonifying spleen and appetizing" 1
• BPTS has demonstrated anti-inflammatory effects by inhibiting proinflammatory mediators, making it useful for treating patients with heat syndrome in Traditional Chinese Medicine 3

Dosing and Administration

• The standard dose of Bangpungtongsung-san dried extract is 237.5mg, though clinical studies have evaluated doses ranging from 500-2000mg/kg/day 2
• Administration should follow traditional methods with syndrome differentiation to maximize efficacy 1
• For respiratory applications, similar traditional herbs are administered 2-3 times daily, which may be applicable to BPTS as well 4

Clinical Evidence and Safety Profile

• Subchronic toxicity studies have shown no treatment-related adverse effects at doses up to 2000 mg/kg/day for 13 weeks, establishing a no-observed-adverse-effect-level (NOAEL) above 2000 mg/kg for both sexes 2
• BPTS has demonstrated significant anti-inflammatory effects through:
  • Inhibition of proinflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), TNF-α, and IL-6 3
  • Suppression of NF-κB and MAPK signaling pathways in LPS-induced macrophages 3
• In animal models, BPTS has shown:
  • Antidepressant effects by reducing immobility time in forced swimming tests and tail suspension tests 5
  • Anti-neuroinflammatory effects by reducing pro-inflammatory cytokines in the hippocampus 5
  • Anti-asthmatic effects by reducing airway remodeling, mucus hyperplasia, and collagen deposition 6

Specific Applications in Traditional Medicine

• BPTS follows the TCM therapeutic method of "strengthening healthy energy and removing blood stasis" 1
• For liver damage, BPTS can be combined with other treatments based on the therapeutic strategy of "strengthening primordial energy, releasing pulmonary qi, nourishing spleen, and detoxification" 1
• BPTS may reduce adverse events of other medications by shortening their application time and total dose through its complementary effects 1

Precautions and Monitoring

• While BPTS has shown a good safety profile, monitoring for potential drug-drug interactions is recommended when used with other medications 1
• For medications with dose-dependent negative effects, minimum effective doses should be used for the shortest duration 1
• Active monitoring and evaluation should follow the TCM theory of "treating the disease before it occurs (preventive treatment of disease)" 1