From the FDA Drug Label
Infrequent: Abnormal ejaculation, Albuminuria, Amenorrhea, Dysmenorrhea, Dysuria, Hematuria, Kidney calculus, Leukorrhea, Menorrhagia, Metrorrhagia, Nephritis, Oliguria, Urinary retention, Urine abnormality;
- Hematuria is listed as an infrequent adverse reaction in the Urogenital System section of the drug label, occurring in 1/100 to 1/1000 patients 1.
- Pregabalin can cause hematuria (blood in urine).
From the Research
Pregabalin can potentially cause hematuria (blood in urine), though it is considered an uncommon side effect, and patients with pre-existing kidney problems should be particularly vigilant. If you notice blood in your urine while taking pregabalin, you should contact your healthcare provider promptly. Pregabalin, marketed under brand names like Lyrica, is primarily used to treat neuropathic pain, epilepsy, fibromyalgia, and generalized anxiety disorder. The mechanism behind pregabalin-induced hematuria is not fully understood but may relate to its effects on renal function or possible hypersensitivity reactions. Other urinary side effects associated with pregabalin include urinary tract infections, urinary frequency, and urinary retention.
Key Considerations
- Patients with decreased kidney function may be at an increased risk of adverse effects, including hematuria, due to the renal clearance of pregabalin 2.
- The relationship between gabapentinoid dosing, kidney function, and the incidence of gabapentinoid-related adverse effects, such as hematuria, requires larger, multicentre studies 2.
- Pregabalin should be used judiciously in patients on hemodialysis, and research to identify the most optimal dosing is warranted 3.
- Patients with pre-existing kidney problems should be particularly vigilant, as pregabalin is primarily excreted by the kidneys and dosage adjustments are often necessary in renal impairment.
Clinical Implications
- If you experience hematuria while on pregabalin, your doctor might consider alternative medications depending on your condition and overall health status.
- It is essential to monitor kidney function and adjust the dosage of pregabalin accordingly to minimize the risk of adverse effects, including hematuria.
- Patients should be aware of the potential risks and benefits of pregabalin and report any unusual symptoms, including hematuria, to their healthcare provider promptly.