Is petrolatum-based antibiotic ointment suitable for burn treatment?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 30, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Petrolatum-Based Antibiotic Ointment for Burn Treatment

Yes, petrolatum-based antibiotic ointment is suitable and recommended for burn treatment, particularly for superficial and first-degree burns. 1, 2

Appropriate Use of Petrolatum-Based Antibiotic Ointments

  • The American College of Cardiology recommends petrolatum-based antibiotic ointments such as bacitracin, Polysporin, or triple-antibiotic ointment combined with clean non-adherent dressings for superficial first-degree burns 1
  • Wounds heal better with less infection when covered with an antibiotic ointment or cream and a clean occlusive dressing 3
  • Polysporin, containing polymyxin B and bacitracin in a petrolatum base, is effective in preventing infection in partial thickness burns 1
  • After cooling a burn, applying a thin layer of petrolatum-based antibiotic ointment directly to the burn is recommended 1, 2

Evidence Supporting Petrolatum-Based Products

  • Research has shown that petrolatum gel alone may be at least as effective as silver sulfadiazine gauze dressings regarding time to re-epithelialization and incidence of infection 4
  • In a randomized controlled trial, mean time to re-epithelialization was 6.2 days with petrolatum compared to 7.8 days with silver sulfadiazine 4
  • Triple-antibiotic petrolatum-based ointment has been shown to enhance re-epithelialization and reduce scar depth and contraction compared with silver-based foam dressings in research models 5
  • Xeroform, a petrolatum-impregnated gauze dressing, provides a non-adherent barrier while allowing exudate to pass through 1

Application Protocol

  • First cool the burn with clean running water for 5-20 minutes to limit tissue damage and reduce pain 1, 2
  • Gently cleanse the wound with tap water or isotonic saline 1
  • Apply a thin layer of petrolatum-based antibiotic ointment directly to the burn 1, 2
  • Cover with a clean, non-adherent dressing 1, 2
  • Change dressings as needed, typically three times weekly for antibiotic ointment 5

Important Considerations and Cautions

  • Bacitracin and other topical antibiotics are for external use only 6
  • Do not use if allergic to any of the ingredients 6
  • Do not use on deep or puncture wounds or serious burns without medical consultation 6
  • Stop use and consult a doctor if you need to use longer than 1 week, condition persists or worsens, or if a rash or allergic reaction develops 6
  • Avoid applying ice directly to burns as this can cause further tissue damage 3, 1
  • Do not apply butter, oil, or other home remedies to burns 1, 2

When to Seek Medical Attention

  • Burns involving the face, hands, feet, or genitalia require specialized care regardless of size 1, 2
  • Burns covering >10% body surface area in adults (>5% in children) should be treated in a specialized burn center 2
  • Seek medical attention for burns that show signs of infection or are very painful 1
  • Consult a healthcare provider for burns that don't show improvement within a week 6

References

Guideline

Management of First-Degree Burns

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Management of Second-Degree Burns

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Topical antibiotic ointment versus silver-containing foam dressing for second-degree burns in swine.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.