What is the recommended dose of Syr Ascoril LS (Levosalbutamol + Guaifenesin) for a 10-year-old girl?

Dosage of Syrup Ascoril LS for a 10-Year-Old Girl

For a 10-year-old girl, the recommended dose of Syrup Ascoril LS (Levosalbutamol + Guaifenesin) is 5 mg/kg/day of levosalbutamol component, divided into two doses. This translates to approximately 5-10 ml twice daily, depending on the specific formulation concentration.

Dosing Guidelines Based on Age and Weight

• For children 10-12 years old, the standard dosing of levosalbutamol (the active bronchodilator component in Ascoril LS) is 5 mg/kg/day divided into two doses 1
• Children who weigh less than 40 kg should receive weight-based dosing at 5 mg/kg/day regardless of age 1
• For a typical 10-year-old girl (approximately 30-35 kg), this would calculate to about 150-175 mg total daily dose of levosalbutamol 1

Administration Guidelines

• The syrup should be administered in two divided doses (morning and evening) 1
• Duration of treatment typically ranges from 5-7 days for acute respiratory conditions, but may be adjusted based on clinical response 2
• The medication should be taken with food to minimize potential gastrointestinal side effects 1

Clinical Considerations

• Levosalbutamol (R-isomer of salbutamol) has been shown to be more effective than racemic salbutamol with fewer side effects in pediatric patients 3
• Monitoring for common side effects is important, including:
  • Mild tremor (reported in approximately 1% of patients) 2
  • Palpitations (reported in approximately 0.9% of patients) 2
  • Vomiting (reported in approximately 0.7% of patients) 2

Special Considerations

• If the child has any renal or hepatic dysfunction, dose reduction may be necessary 1
• For children with asthma or significant bronchospasm, having a fast-acting bronchodilator available during treatment is recommended 1
• The dose should not exceed the maximum recommended daily dose of 150 mg for children in this age group 1

Common Pitfalls to Avoid

• Avoid underdosing, which may lead to inadequate symptom control 3
• Avoid overdosing, which may increase risk of side effects like tachycardia and tremors 2
• Do not continue treatment beyond 7-10 days without reassessment, as prolonged use may lead to tolerance 2
• Do not administer with other beta-agonist medications without appropriate spacing to avoid additive effects 1