Differential Diagnosis
- Single most likely diagnosis
- IgA Nephropathy: This condition is characterized by the deposition of IgA antibodies in the kidneys, which can lead to acute kidney injury and high blood pressure. The homogenous pattern of FANA (Fluorescent Antinuclear Antibody) staining is consistent with IgA Nephropathy, and the negative lupus testing helps to rule out other autoimmune causes.
- Other Likely diagnoses
- Post-Infectious Glomerulonephritis: This condition can cause acute kidney injury and high blood pressure, and may exhibit a homogenous pattern of FANA staining. However, the normal complement levels make this diagnosis less likely.
- Membranous Nephropathy: This condition is characterized by the deposition of immune complexes in the kidneys, which can lead to kidney injury and high blood pressure. While the FANA staining pattern is not specific for this condition, it is a possible cause of the patient's symptoms.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Goodpasture's Syndrome: This rare autoimmune disorder is characterized by the presence of anti-GBM (glomerular basement membrane) antibodies, which can cause rapid kidney failure and high blood pressure. Although the lupus testing is negative, Goodpasture's Syndrome can present with a homogenous pattern of FANA staining, and the consequences of missing this diagnosis can be severe.
- ANCA-Associated Vasculitis: This group of conditions, including Granulomatosis with Polyangiitis and Microscopic Polyangiitis, can cause kidney injury and high blood pressure, and may exhibit a homogenous pattern of FANA staining. While the normal complement levels make this diagnosis less likely, it is still important to consider due to the potential severity of the condition.
- Rare diagnoses
- Alport Syndrome: This genetic disorder is characterized by the presence of anti-GBM antibodies and can cause kidney failure and high blood pressure. However, it is a rare condition and typically presents at a younger age.
- C3 Glomerulopathy: This group of conditions is characterized by the deposition of complement components in the kidneys, which can lead to kidney injury and high blood pressure. However, the normal complement levels make this diagnosis less likely.