Major Depressive Disorder (MDD) with Irritability: This is often characterized by persistent feelings of sadness or a lack of interest in external stimuli, which can manifest as irritability or anger outbursts, especially in men or in certain cultural contexts.

Bipolar Disorder: Anger outbursts can be a feature of manic or hypomanic episodes, and depressive episodes can also occur, making this a plausible diagnosis.
Borderline Personality Disorder: Characterized by a pattern of varying moods, self-image, and behavior, which can result in intense episodes of anger, depression, and anxiety.
Intermittent Explosive Disorder: Defined by recurrent, problematic, impulsive aggression, which could be a primary diagnosis if the anger outbursts are the predominant symptom.
Substance-Induced Mood Disorder: Certain substances can induce mood changes, including depression and irritability, which could be a consideration if there's a history of substance use.

Hypothyroidism: Although less common, hypothyroidism can cause mood changes, including depression and irritability, making it crucial not to miss this diagnosis due to its significant impact on quality of life and the availability of effective treatment.
Neurodegenerative Diseases (e.g., Frontotemporal Dementia): Certain neurodegenerative diseases can present with significant mood and personality changes, including anger outbursts and depression, early in their course.
Traumatic Brain Injury: Previous head injuries could lead to mood instability, including depression and anger issues, due to the impact on brain function.

Wilson's Disease: A rare genetic disorder that leads to copper accumulation in the body, affecting the brain and liver, and can cause psychiatric symptoms, including mood swings and depression.
Pseudobulbar Affect: A condition characterized by episodes of sudden uncontrollable and inappropriate laughing or crying, which can sometimes be mistaken for mood disorders.
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: While primarily known for causing profound fatigue, some patients may experience mood disturbances, including irritability and depression.