From the Guidelines
The dosing regimen for Novolin (Novolog) 70/30, a premixed insulin formulation, typically involves twice-daily injections, with 2/3 of the total dose given before breakfast and 1/3 given before dinner, as suggested by the most recent guidelines 1. When determining the initial dose, consider starting with 0.3-0.5 units per kilogram of body weight per day, divided between the morning and evening doses.
- Key factors to consider when adjusting the dose include: + Weight + Insulin sensitivity + Carbohydrate intake + Blood glucose targets
- Dose adjustments should be made gradually, typically by 2-4 units every 3-7 days, based on blood glucose monitoring results, to minimize the risk of hypoglycemia. The premixed formulation of Novolin 70/30 provides both immediate and extended glucose control, with the short-acting component addressing postprandial glucose spikes and the intermediate-acting component providing basal coverage between meals and overnight 1.
- Patients should be educated to monitor for hypoglycemia, particularly during peak action times of the insulin components, and to adjust their diet and exercise accordingly to maintain optimal blood glucose levels.
From the Research
Dosing Regimen for Novolin (Novolog) 70/30
The dosing regimen for Novolin (Novolog) 70/30, a premixed insulin formulation, can vary depending on the patient's specific needs and medical conditions.
- According to the study 2, biphasic human insulin 70/30 can be administered once daily, 30 minutes before dinner, in combination with metformin.
- The study 3 recommends a basal-bolus approach using 0.5 U/kg basal insulin and 0.1 U/kg rapid analog at each meal, but also suggests that patients receiving continuous tube feedings can receive premixed 70/30 insulin every 8 hours.
- The study 4 administered human premixed insulin (30/70) subcutaneously twice daily, before breakfast and before dinner.
- The study 5 added a third injection of biphasic insulin aspart 70/30 just before lunch in older patients with type 2 diabetes who did not achieve optimal glycemic control on a twice-daily regimen.
- The study 6 compared the safety and efficacy of biphasic insulin aspart 70/30 (prebreakfast and presupper) with once-daily insulin glargine in type 2 diabetic subjects inadequately controlled on oral antidiabetic drugs.
Key Considerations
- The dosing regimen for Novolin (Novolog) 70/30 should be individualized based on the patient's specific needs and medical conditions 2, 3, 4, 5, 6.
- The administration of premixed 70/30 insulin can be adjusted based on the patient's meal schedule and glucose levels 3.
- The addition of a third injection of biphasic insulin aspart 70/30 can improve glycemic control in patients who do not achieve optimal control on a twice-daily regimen 5.