Is it safe to take Gray Matter vitamin supplement with Seroquel (quetiapine) and Adderall (amphetamine and dextroamphetamine)?

Safety of Gray Matter Vitamin Supplement with Seroquel and Adderall

Taking Gray Matter vitamin supplement with Seroquel (quetiapine) and Adderall (amphetamine-dextroamphetamine) is potentially unsafe due to the risk of drug interactions, particularly between Adderall and certain vitamin components that could affect serotonergic pathways.

Potential Interactions and Concerns

• Adderall (amphetamine-dextroamphetamine) is contraindicated for use in combination with monoamine oxidase inhibitors (MAOIs) due to risk of hypertensive crisis 1
• Some vitamin supplements, particularly those containing B vitamins or herbal components, may have mild MAOI properties that could interact with Adderall 2
• The combination of serotonergic medications (like some components in vitamin supplements) with sympathomimetic drugs like Adderall requires caution due to potential for adverse reactions 2
• Patients taking multiple medications should be particularly careful with herbal and dietary supplements as nearly 25% of U.S. adults report concurrently taking prescription medications with dietary supplements 3

Specific Medication Considerations

Adderall (Amphetamine-Dextroamphetamine)

• Acts as an adrenergic agonist that promotes release of norepinephrine affecting both α- and β-adrenergic receptor sites 4
• Can cause hyperactivity, hyperthermia, tachycardia, tachypnea, mydriasis, tremors, and seizures in overdose situations 4
• Has significant potential for abuse as a DEA Schedule II controlled substance 4

Seroquel (Quetiapine)

• Atypical antipsychotic that interacts with a broad range of neurotransmitter receptors 5
• Has higher affinity for serotonin (5-HT2A) receptors relative to dopamine (D2) receptors 5
• Generally has a relatively benign side effect profile compared to other antipsychotics 5

Gray Matter Vitamin Supplement Considerations

• While specific information about "Gray Matter" vitamin supplement is not provided in the evidence, B-vitamin supplements (which are commonly included in brain health formulations) can affect homocysteine levels and potentially impact gray matter volumes 6
• Some vitamin supplements contain herbal ingredients that may cause clinically important drug interactions 3
• Without knowing the exact composition of the Gray Matter supplement, it's impossible to rule out potential interactions with either medication

Recommendations

• Do not take Gray Matter vitamin supplement with Adderall and Seroquel without consulting your healthcare provider first 2, 3
• If you wish to take a vitamin supplement, consult with your prescribing physician or pharmacist to review the specific ingredients in Gray Matter supplement for potential interactions 3
• Be particularly vigilant about supplements containing St. John's wort or other herbs known to have MAOI properties, as these should be strictly avoided when taking Adderall 1, 3
• Monitor for signs of serotonin syndrome if you do take these medications together, including mental status changes, neuromuscular hyperactivity, and autonomic hyperactivity 2
• Consider alternative vitamin formulations specifically reviewed by your healthcare provider for safety with your current medication regimen 3

Important Precautions

• Always disclose all supplements you are taking to your healthcare providers, as most patients do not disclose supplement use to clinicians 3
• If you experience symptoms such as increased heart rate, blood pressure changes, agitation, or unusual neurological symptoms after starting the supplement, discontinue use and contact your healthcare provider immediately 2, 4
• Regular monitoring of blood pressure and heart rate is essential when using Adderall, especially when combined with other medications 7