From the FDA Drug Label
Palpitation 3 2 Tachycardia 2 0 The most common signs and symptoms associated with non–fatal overdosage were seizures, somnolence, nausea, tachycardia, and vomiting.
Heart Palpitations are reported as a side effect in:
- Ropinirole: 3% of patients
- Fluoxetine: associated with non-fatal overdosage, but no specific percentage is given for therapeutic use
There is no information about heart palpitations caused by atorvastatin, gabapentin, hydrocodone-homatropine, promethazine, or albuterol sulfate in the provided drug labels 1, 2.
From the Research
Yes, several of the medications listed can commonly cause heart palpitations, particularly fluoxetine, albuterol sulfate, and ropinirole, which are known to affect the autonomic nervous system or directly influence cardiac function. Fluoxetine (an SSRI antidepressant) may cause palpitations in some patients, particularly when starting treatment or adjusting dosage 3, 4, 5. Albuterol sulfate inhaler is well-known for causing palpitations and increased heart rate as a direct effect of its stimulation of beta-2 receptors in the heart. Ropinirole (used for restless legs syndrome or Parkinson's disease) lists palpitations as a recognized side effect. Hydrocodone-homatropine syrup and promethazine can occasionally cause cardiac effects including palpitations in sensitive individuals.
Gabapentin and atorvastatin are less commonly associated with palpitations, though they can occur in rare cases. Notably, atorvastatin has been shown to have a positive effect on heart rate variability and QT interval duration in patients with advanced chronic heart failure, which may suggest a lower risk of palpitations 6. However, it is essential to consider the potential for drug interactions, especially with fluoxetine, which can inhibit the metabolism of other medications and increase the risk of adverse effects 7.
If you're experiencing palpitations while taking these medications, it's crucial to contact your healthcare provider, as dosage adjustments or medication changes may be necessary, especially if the palpitations are severe, persistent, or accompanied by other symptoms like dizziness or shortness of breath. The healthcare provider can assess the situation and make informed decisions based on the individual's medical history and current condition.