From the Research
Acanthosis nigricans is primarily caused by insulin resistance, which is often associated with obesity, type 2 diabetes, and other metabolic disorders, as evident from the most recent study published in 2022 1. The condition is characterized by dark, velvety skin patches typically found in body folds like the neck, armpits, and groin. Several conditions can trigger this process, including:
- Obesity (the most common cause)
- Type 2 diabetes
- Polycystic ovary syndrome (PCOS)
- Hormonal disorders like Cushing's syndrome or acromegaly
- Certain medications such as corticosteroids, niacin, birth control pills, and growth hormones In rare cases, acanthosis nigricans can be associated with certain cancers, particularly stomach cancer, as mentioned in a study published in 2018 2. The condition itself isn't harmful but serves as an important visual indicator of underlying metabolic issues. Treatment focuses on addressing the root cause rather than the skin changes directly, with weight loss and improved blood sugar control often leading to improvement in obesity-related cases, while switching medications may help when drug-induced, as suggested by a study published in 2020 3. If you notice these skin changes, it's essential to consult a healthcare provider to identify and treat the underlying cause, as emphasized in a study published in 2000 4 and further supported by a study published in 1992 5. Early recognition of acanthosis nigricans is crucial because it can be a cutaneous manifestation of a variety of systemic disorders and, rarely, as a sign of internal malignancy, highlighting the importance of regular check-ups and screenings.