Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 31, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Upper Left Abdominal Quadrant Pain

Single Most Likely Diagnosis

  • Constipation: Given the patient's hard bowel movements for 2 days and low water intake (2-3 cups daily), constipation is the most likely cause of the upper left abdominal quadrant pain. The fact that Miralax (a laxative) was given also points towards this diagnosis.

Other Likely Diagnoses

  • Gastroesophageal Reflux Disease (GERD): Although the patient does not have nausea or vomiting, GERD can cause upper abdominal pain that may be referred to the left upper quadrant.
  • Peptic Ulcer Disease: Peptic ulcers can cause intermittent abdominal pain, and the location of the pain can sometimes be in the left upper quadrant, especially if the ulcer is located in the duodenum or the stomach.
  • Diverticulitis: While more common on the left lower side, diverticulitis can occasionally cause pain in the upper left quadrant if the diverticula are located in the upper parts of the colon.

Do Not Miss Diagnoses

  • Splenic Infarct or Rupture: These conditions can cause severe left upper quadrant pain and are medical emergencies. Although less likely, they must be considered, especially if the patient has a history of trauma, sickle cell disease, or other conditions that predispose to splenic issues.
  • Pancreatitis: Pancreatitis can cause severe upper abdominal pain that radiates to the back and can be a life-threatening condition if not promptly diagnosed and treated.
  • Pneumonia (Left Lower Lobe): Sometimes, pneumonia can cause referred pain to the abdomen, and it's crucial to consider this diagnosis, especially if the patient has respiratory symptoms or risk factors for pneumonia.

Rare Diagnoses

  • Gastric Volvulus: A rare condition where the stomach twists abnormally, causing severe upper abdominal pain.
  • Intestinal Obstruction: Although more common in the lower abdomen, an obstruction in the upper gastrointestinal tract can cause pain in the left upper quadrant.
  • Left Diaphragmatic Hernia: A rare condition where abdominal contents herniate through the diaphragm, causing upper abdominal pain and potentially life-threatening complications if not recognized.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.