What is the dosage of Spruce?

From the Guidelines

The dosage of Spruce is not explicitly mentioned in the provided evidence, but based on the context, it appears that the question is referring to a medication, and the evidence provided is about different medications, likely antibiotics or antimycobacterials, with varying dosages.

Medication Dosage

• The dosage of the medication in question is not clear, but the provided evidence suggests that the dosage of similar medications can range from 300 mg to 750 mg per day, depending on the patient's age and weight, as well as the specific medication being used 1.

Specific Dosage Recommendations

• For adults, the dosage can range from 300 mg to 600 mg per day, with some medications requiring twice-daily dosing 1.
• For children, the dosage is typically based on weight, with recommendations ranging from 5 mg/kg to 10 mg/kg per day 1.
• It's worth noting that the evidence provided is from 2017 guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), and the dosages recommended may not be applicable to other contexts or medications 1.

From the Research

Dosage of Spruce

The dosage of spruce is not directly stated in most of the provided studies. However, some studies provide information on the dosage of spruce extracts or preparations:

• The study 2 administered Ropren(®) at a dose of 8.6mg/kg for 28 days to rats with β-amyloid peptide-(25-35)-induced amnesia.
• The study 3 administered water-extracted spruce bark daily for 12 days to Eimeria-infected pre-ruminant lambs, but the exact dosage is not specified.
• The study 4 discusses the importance of proper dosage form design and development, but does not provide specific information on the dosage of spruce.

Key Findings

Some key findings related to the dosage of spruce include:

• The study 2 found that Ropren(®) treatment significantly improved non-spatial and spatial learning in rats with β-amyloid peptide-(25-35)-induced amnesia.
• The study 3 found that oral administration of spruce bark extract significantly reduced the excretion of Eimeria oocysts in milk-fed lambs, but also had detrimental effects on feed intake and daily body weight gain.
• The study 4 highlights the importance of considering physical, chemical, and biological characteristics of drug substances and pharmaceutical ingredients when designing a dosage form.

Dosage Considerations

Considerations for the dosage of spruce include:

• The study 3 suggests that lower dosages of spruce bark extract may be necessary to reduce negative impacts while maintaining antiparasitic effects.
• The study 4 emphasizes the need for proper formulation and design of dosage forms to ensure stability, efficacy, and palatability.