Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 31, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Blood in Sputum

Single Most Likely Diagnosis

  • Chronic Bronchitis: This condition is often associated with smoking and can lead to the production of blood-tinged sputum due to chronic inflammation and irritation of the bronchial tubes.

Other Likely Diagnoses

  • Pneumonia: Bacterial, viral, or fungal infections can cause inflammation in the lungs, leading to bleeding into the airspaces and resulting in blood in the sputum.
  • Acute Bronchitis: Similar to chronic bronchitis but typically caused by an infectious agent, leading to inflammation and potential bleeding in the bronchial tubes.
  • Tuberculosis (TB): A chronic bacterial infection that can cause coughing up of blood due to the destruction of lung tissue.

Do Not Miss Diagnoses

  • Lung Cancer: Although less common, lung cancer can present with hemoptysis (coughing up blood) and is critical to diagnose early for potential treatment.
  • Pulmonary Embolism: A blood clot in the lungs can cause sudden onset of chest pain, shortness of breath, and potentially blood in the sputum, which is a medical emergency.
  • Mitral Stenosis: A heart condition where the mitral valve narrows, potentially leading to increased pressure in the lungs and subsequent bleeding.

Rare Diagnoses

  • Goodpasture Syndrome: A rare autoimmune disease that can cause bleeding in the lungs and kidneys.
  • Wegener's Granulomatosis (Granulomatosis with Polyangiitis): A rare autoimmune disorder that can affect various parts of the body, including the lungs, and cause bleeding.
  • Bronchiectasis: A condition where parts of the airways are permanently enlarged, leading to chronic infections and potential bleeding.
  • Cystic Fibrosis: A genetic disorder that leads to severe respiratory and digestive problems, and can cause hemoptysis due to chronic infection and inflammation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.