Viral Exanthem: This is the most common cause of a splotchy rash in infants, often associated with viral infections such as roseola, measles, or rubella. The rash typically appears after a few days of fever and resolves on its own.

Eczema (Atopic Dermatitis): A common condition in infants characterized by itchy, inflamed skin. It often starts as a splotchy rash on the face, scalp, or extremities.
Contact Dermatitis: An allergic reaction or irritation caused by substances like soaps, detergents, or certain fabrics, leading to a splotchy rash.
Impetigo: A bacterial infection of the skin that can cause a splotchy, red rash, often with pus-filled blisters.

Meningococcemia: A severe, life-threatening infection caused by Neisseria meningitidis, which can present with a petechial or purpuric rash (small, pinpoint spots that do not blanch with pressure). Early recognition is crucial for treatment.
Kawasaki Disease: An acute febrile illness that can cause a splotchy rash, along with other symptoms like fever, conjunctivitis, and swollen lymph nodes. If untreated, it can lead to serious cardiac complications.
Staphylococcal Scalded Skin Syndrome (SSSS): A condition caused by staphylococcal toxins that can lead to widespread skin blistering and peeling, often starting with a splotchy, red rash.

Incontinentia Pigmenti: A rare genetic disorder that affects the skin, hair, teeth, and central nervous system, characterized by a splotchy rash that evolves into hyperpigmentation.
Blue Rubber Bleb Nevus Syndrome: A rare condition characterized by multiple venous malformations that can appear as a splotchy, blue-colored rash.
Congenital Syphilis: A condition that occurs when a baby is born with syphilis, which can cause a variety of skin rashes, including a splotchy appearance.