Differential Diagnosis for Abnormal Liver Functions and Painless Jaundice
Single Most Likely Diagnosis
- Hemochromatosis: Given the significantly elevated ferritin level (7092) and high iron level (59), along with abnormal liver functions and evidence of liver damage (elevated AST, ALT, and bilirubin), hemochromatosis is a strong consideration. The condition leads to iron overload, which can cause liver damage, among other complications.
Other Likely Diagnoses
- Non-Alcoholic Steatohepatitis (NASH): The presence of fatty liver on CT, elevated liver enzymes (AST, ALT), and the patient's overall clinical presentation could suggest NASH, especially given the context of potentially metabolic syndrome indicators (though not all are provided).
- Viral Hepatitis: Although the specific viral markers are not provided, the significant elevation in liver enzymes (AST, ALT) could indicate an acute or chronic viral hepatitis infection.
- Autoimmune Hepatitis: The elevated liver enzymes and the presence of jaundice could also suggest autoimmune hepatitis, particularly if autoimmune markers are positive (though not provided in the scenario).
Do Not Miss Diagnoses
- Wilson's Disease: This is a genetic disorder leading to copper accumulation in the liver, which can present with liver dysfunction, jaundice, and potentially severe consequences if not treated. It's crucial to consider, especially in younger patients, though the age here is 52.
- Budd-Chiari Syndrome: Given the presence of ascites suggested by gallbladder wall thickening and the significant liver dysfunction, Budd-Chiari syndrome (hepatic vein thrombosis) should be considered, as it can lead to rapid deterioration if not addressed.
- Hepatocellular Carcinoma: In the context of chronic liver disease (suggested by abnormal liver functions and imaging findings), hepatocellular carcinoma is a critical diagnosis not to miss, as it requires prompt intervention.
Rare Diagnoses
- Alpha-1 Antitrypsin Deficiency: A genetic disorder that can lead to liver disease and might present with abnormal liver functions and potentially lung disease.
- Primary Biliary Cholangitis (PBC): An autoimmune disease of the liver that can lead to cholestasis and liver damage over time. It's less likely given the acute presentation but should be considered in the differential for chronic liver disease.
- Primary Sclerosing Cholangitis (PSC): Another autoimmune condition affecting the bile ducts, leading to cholestasis and potentially severe liver disease. It's rare and might be considered if other autoimmune markers are positive or if there's a history suggestive of inflammatory bowel disease.