What are the causes of left-sided numbness (paresthesia)?

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Last updated: March 27, 2025 • View editorial policy

Differential Diagnosis for Left Sided Numbness

  • Single Most Likely Diagnosis + Stroke or Transient Ischemic Attack (TIA): This is the most likely diagnosis due to the sudden onset of numbness on one side of the body, which is a classic symptom of a stroke or TIA. The numbness can be accompanied by other symptoms such as weakness, facial drooping, and speech difficulties.
  • Other Likely Diagnoses + Multiple Sclerosis: This is an autoimmune disease that affects the central nervous system, causing symptoms such as numbness, weakness, and vision problems. The numbness can be unilateral and may be accompanied by other symptoms such as optic neuritis and bladder dysfunction. + Peripheral Neuropathy: This is a condition that causes damage to the peripheral nerves, leading to symptoms such as numbness, tingling, and weakness. The numbness can be unilateral and may be accompanied by other symptoms such as pain and sensory loss. + Radiculopathy: This is a condition that affects the nerve roots, causing symptoms such as numbness, weakness, and pain. The numbness can be unilateral and may be accompanied by other symptoms such as muscle weakness and reflex changes.
  • Do Not Miss Diagnoses + Spinal Cord Compression: This is a serious condition that requires immediate attention, as it can cause permanent damage to the spinal cord. Symptoms include numbness, weakness, and loss of bladder and bowel function. + Brain Tumor: This is a rare but serious condition that can cause numbness, weakness, and other neurological symptoms. A brain tumor can be life-threatening if left untreated. + Vasculitis: This is a condition that causes inflammation of the blood vessels, leading to symptoms such as numbness, weakness, and pain. Vasculitis can be life-threatening if left untreated.
  • Rare Diagnoses + Lyme Disease: This is a rare condition that can cause numbness, weakness, and other neurological symptoms. Lyme disease is caused by a bacterial infection and can be treated with antibiotics. + Sjögren's Syndrome: This is a rare autoimmune disease that can cause numbness, weakness, and other neurological symptoms. Sjögren's syndrome is often associated with other symptoms such as dry eyes and mouth. + Neuropathy due to Vitamin Deficiency: This is a rare condition that can cause numbness, weakness, and other neurological symptoms due to a deficiency in vitamins such as B12 or vitamin E.

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