How to use Vtama (topical retinoid cream)?

How to Use Vtama Cream

Apply a thin layer of Vtama cream to affected areas once daily and wash hands after application unless treating the hands. 1

Application Instructions

• Apply Vtama cream exactly as prescribed by your healthcare provider 1
• Use only on affected skin areas, avoiding unaffected areas 1
• Apply a thin layer once daily 1
• Wash hands thoroughly after application unless Vtama is being used to treat the hands 1
• If someone else is applying the cream for you, they should also wash their hands after application 1

Important Precautions

• Vtama cream is for external use only - do not use in eyes, mouth, or vagina 1
• Store at room temperature between 68°F to 77°F (20°C to 25°C) 1
• Protect from excessive heat and do not freeze 1
• Keep out of reach of children 1

Indications

• Vtama (tapinarof) cream 1% is FDA-approved for:
  • Plaque psoriasis in adults 1, 2
  • Atopic dermatitis in adults and children 2 years of age and older 1, 3

Mechanism of Action

• Tapinarof is an aryl hydrocarbon receptor (AhR) agonist 2
• AhR is a ligand-dependent transcription factor with a role in immune-mediated skin responses and maintaining skin homeostasis 2, 3

Potential Side Effects

• Most common side effects in plaque psoriasis treatment include:

  • Folliculitis (red raised bumps around hair pores) 1, 4
  • Nasopharyngitis (pain or swelling in nose and throat) 1
  • Skin irritation (itching, redness, peeling, burning, or stinging) 1, 5
  • Headache 1, 4

• Most common side effects in atopic dermatitis treatment include:

  • Upper and lower respiratory tract infections 1
  • Folliculitis 1
  • Headache 1
  • Contact dermatitis may occur in some patients 4

• Monitor for skin reactions at the treatment site and report any concerning symptoms to your healthcare provider 1

Safety Profile

• Clinical trials have shown Vtama cream 1% to be well-tolerated with low discontinuation rates 5
• Dermal safety studies have demonstrated that Vtama cream 1% is:
  • Non-sensitizing
  • Non-phototoxic
  • Non-photoallergic
  • Has only slight potential for very mild cumulative irritation 5

Special Populations

• Pregnancy: It is not known if Vtama cream will harm an unborn baby 1
• Breastfeeding: It is not known if Vtama cream passes into breast milk 1
• Pediatric use: Safe and effective for atopic dermatitis in children 2 years and older, but not established for plaque psoriasis in children 1, 3