From the FDA Drug Label
Plasbumin-25 is a 25% sterile solution of albumin in an aqueous diluent. The amount of albumin in a 25% solution is 25%, which means there are 25 grams of albumin per 100 milliliters of solution 1.
From the Research
A 25% albumin solution contains 25 grams of albumin per 100 milliliters of solution, which translates to 0.25 grams (250 mg) of albumin per milliliter. This information is crucial for understanding the concentration and potential effects of 25% albumin solutions in clinical settings 2. For context, 25% albumin is a hyperoncotic solution, more concentrated than standard 5% albumin solutions. When administered, this concentrated albumin creates a strong oncotic pressure gradient that pulls fluid from the interstitial space into the intravascular compartment. This makes 25% albumin particularly useful in clinical situations requiring rapid plasma volume expansion with minimal fluid administration, such as in patients with hypoalbuminemia, hepatorenal syndrome, or certain types of edema where fluid restriction is necessary.
Clinical Use and Considerations
The typical dose ranges from 50-100 mL (12.5-25 grams of albumin), but specific dosing should be determined based on the patient's clinical condition, weight, and albumin levels 2. Administration should be done slowly to prevent rapid fluid shifts and potential circulatory overload. It's also important to note that the use of 25% human albumin solution could effectively manage ascites in patients with cirrhosis, reducing the volume of fluids administered and allowing a faster achievement of the plasma target concentration.
Safety and Monitoring
While 25% albumin solutions are valuable in certain clinical scenarios, their use must be carefully considered, especially regarding potential risks and the need for monitoring. The solution should not be diluted with sterile water alone, as this can cause hemolysis due to reduced osmolarity 3. Instead, dilution should be done with appropriate solutions like 0.9% NaCl or 5% dextrose when necessary. The choice of diluent is critical to avoid adverse effects.
Evidence Summary
The most recent and highest quality study relevant to the question of the amount of albumin in a 25% solution and its clinical implications is from 2024 2. This study emphasizes the importance of understanding the concentration of albumin solutions and their appropriate use in clinical practice, highlighting the benefits and risks associated with 25% human albumin solution.
Key Points
- A 25% albumin solution contains 25 grams of albumin per 100 milliliters.
- It is used for rapid plasma volume expansion with minimal fluid administration.
- Typical dose ranges from 50-100 mL, depending on the patient's condition.
- Administration should be slow to prevent circulatory overload.
- Dilution should be done carefully to avoid hemolysis.