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Differential Diagnosis for Nausea/Vomiting in the 1st Trimester

Single Most Likely Diagnosis

  • Morning Sickness: This is the most common cause of nausea and vomiting in the first trimester, affecting up to 80% of pregnant women. It is thought to be related to hormonal changes, particularly the increase in human chorionic gonadotropin (hCG) levels.

Other Likely Diagnoses

  • Gastroenteritis: Viral or bacterial infections can cause nausea and vomiting, and are common in the general population, including pregnant women.
  • Food Poisoning: Consuming contaminated food can lead to nausea and vomiting, and pregnant women may be more susceptible due to changes in their immune system.
  • Urinary Tract Infection (UTI): While not as common as other causes, UTIs can cause nausea and vomiting, especially if they progress to pyelonephritis.
  • Hyperemesis Gravidarum: A more severe form of morning sickness, characterized by persistent and severe vomiting, leading to dehydration and weight loss.

Do Not Miss Diagnoses

  • Ectopic Pregnancy: Although less common, ectopic pregnancy is a life-threatening condition that can present with nausea and vomiting, along with abdominal pain and vaginal bleeding.
  • Appendicitis: Appendicitis can cause nausea and vomiting, and is a surgical emergency that requires prompt diagnosis and treatment.
  • Preeclampsia: While typically presenting with hypertension and proteinuria, preeclampsia can also cause nausea and vomiting, and is a serious condition that requires close monitoring.
  • Molar Pregnancy: A rare condition where a non-viable fertilized egg implants in the uterus, causing severe nausea and vomiting, along with other symptoms.

Rare Diagnoses

  • Adrenal Insufficiency: A rare condition where the adrenal glands do not produce enough hormones, leading to nausea and vomiting, among other symptoms.
  • Thyroid Storm: A life-threatening condition caused by excessive thyroid hormone production, which can cause nausea and vomiting, along with other symptoms such as palpitations and fever.
  • Pancreatitis: Inflammation of the pancreas, which can cause nausea and vomiting, along with abdominal pain and other symptoms.
  • Gallbladder Disease: Gallstones or cholecystitis can cause nausea and vomiting, especially after eating fatty foods.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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