What are the Indian brands of voriconazole (antifungal medication)?

Indian Brands of Voriconazole

There is no specific information about Indian brands of voriconazole in the provided evidence. The guidelines and research articles focus on clinical uses, dosing, and efficacy of voriconazole but do not list commercial brand names available in India.

General Information About Voriconazole

• Voriconazole is a second-generation triazole antifungal agent with broad-spectrum activity against various fungi including Aspergillus species, Candida species, Scedosporium, and Fusarium species 1
• It is available in both intravenous and oral formulations, with excellent bioavailability when taken orally 2, 3
• Voriconazole is the treatment of choice for invasive aspergillosis and can also be used for treating serious Candida infections, particularly those resistant to fluconazole 4, 2

Clinical Applications

• Voriconazole is indicated for:
  • Invasive aspergillosis (primary treatment) 4, 5
  • Candidemia in non-neutropenic patients 4, 2
  • Esophageal candidiasis (treatment duration 14-21 days) 4
  • CNS fungal infections (due to good CNS penetration) 4
  • Infections caused by Scedosporium and Fusarium species that are refractory to other antifungal therapy 2, 1

Administration Considerations

• Oral voriconazole tablets can be administered either whole or crushed without significant differences in bioavailability, which may be useful in certain clinical scenarios 6
• Treatment duration for invasive aspergillosis should continue until resolution or stabilization of all clinical and radiographic manifestations 4
• For candidemia, treatment should continue for at least 14 days after resolution of symptoms or last positive culture, whichever is longer 4

Side Effects and Monitoring

• Common adverse effects include:
  • Transient visual disturbances (approximately 30% of patients) 5, 1
  • Skin rash and photosensitivity 1, 3
  • Hepatic enzyme elevations 3
• With prolonged use, additional adverse effects may include periostitis, alopecia, and development of skin cancers 3
• Therapeutic drug monitoring is essential due to unpredictable, nonlinear pharmacokinetics with extensive interpatient and intrapatient variation in serum levels 3
• Numerous drug interactions require careful attention to dosage regimens and monitoring 2, 1, 3

Important Considerations

• Drug-drug interactions are common with voriconazole, particularly with anticonvulsants in patients with CNS infections 4, 3
• Follow-up blood cultures should be obtained for all patients with candidemia to ensure clearance 4