Is petroleum jelly (Vaseline) effective for atopic dermatitis (eczema)?

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Last updated: March 27, 2025View editorial policy

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From the Guidelines

Vaseline (petroleum jelly) is a recommended emollient for atopic dermatitis (eczema) as it helps create a protective barrier on the skin, locking in moisture and preventing irritants from causing flare-ups. According to the guidelines of care for the management of atopic dermatitis in adults with phototherapy and systemic therapies 1, emollients and prescription topical therapies are sufficient to achieve AD control for most people with atopic dermatitis. The American Academy of Dermatology (AAD) guidelines suggest that there are several effective topical treatments available for AD, including emollients like Vaseline 1.

To use Vaseline effectively for eczema, apply a thin layer to affected areas after bathing while the skin is still slightly damp, and reapply as needed throughout the day, especially after washing hands or when the skin feels dry. It is essential to use Vaseline as part of a daily skincare routine that includes gentle, fragrance-free cleansers and regular moisturizing. Vaseline works by creating an occlusive barrier that prevents transepidermal water loss, which is particularly beneficial for eczema sufferers whose skin barrier function is compromised 1.

While Vaseline won't treat the underlying inflammation of eczema, it can significantly reduce symptoms like dryness, itching, and cracking. For severe eczema, combine Vaseline with prescribed medications like topical corticosteroids or other treatments recommended by your healthcare provider. The decision to initiate these more advanced therapies should be made using shared decision-making between patients and clinicians, taking into account the severity of AD, its impact on the patient, and the efficacy, safety, and accessibility of the available interventions 1.

Key points to consider when using Vaseline for eczema include:

  • Apply a thin layer to affected areas after bathing
  • Reapply as needed throughout the day
  • Use as part of a daily skincare routine with gentle, fragrance-free cleansers and regular moisturizing
  • Combine with prescribed medications for severe eczema
  • Consider the severity of AD, its impact on the patient, and the efficacy, safety, and accessibility of available interventions when deciding on treatment options 1.

From the Research

Effectiveness of Petroleum Jelly (Vaseline) for Atopic Dermatitis (Eczema)

  • There is no direct evidence in the provided studies to support the effectiveness of petroleum jelly (Vaseline) for atopic dermatitis (eczema) 2, 3, 4, 5, 6.
  • However, the studies suggest that moisturizers and emollients can be beneficial in reducing eczema symptoms and improving skin health 4, 5.
  • A study found that mildly alkaline topical creams can provide soothing effects on eczema-related skin inflammation 4.
  • Another study found that moisturizers can reduce eczema severity, itch, and flares, and improve skin barrier function 5.
  • The use of topical corticosteroids, topical calcineurin inhibitors, and other anti-inflammatory treatments are also effective in managing eczema symptoms 2, 3, 6.

Key Findings

  • Moisturizers and emollients can be beneficial in reducing eczema symptoms and improving skin health 4, 5.
  • Topical corticosteroids and topical calcineurin inhibitors are effective in managing eczema symptoms 2, 3, 6.
  • There is no evidence to support the use of oral antihistamines, oral or topical antistaphylococcal treatments, or probiotics for treating eczema 6.
  • Nonpharmacological treatments such as silk clothing, ion-exchange water softeners, and emollient bath additives have not been shown to benefit eczema patients 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Topical anti-inflammatory treatments for eczema: network meta-analysis.

The Cochrane database of systematic reviews, 2024

Research

Topical Anti-Inflammatory Treatments for Eczema: A Cochrane Systematic Review and Network Meta-Analysis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2024

Research

Emollients and moisturisers for eczema.

The Cochrane database of systematic reviews, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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