What is the dosage for fluconazole (antifungal medication) 100mg tablets?

Fluconazole 100mg Tablet Dosing

Fluconazole 100mg tablets are dosed once daily, with the specific indication determining whether this is used as maintenance therapy after a loading dose or as the primary treatment dose.

Oropharyngeal Candidiasis (Oral Thrush)

• For moderate to severe oropharyngeal candidiasis, administer fluconazole 100-200 mg once daily for 7-14 days 1, 2
• The standard regimen uses a 200 mg loading dose on day 1, followed by 100 mg once daily thereafter 3
• Treatment duration should be at least 2 weeks to decrease likelihood of relapse 3
• For mild disease, topical agents (clotrimazole troches) are preferred over systemic fluconazole 1, 2

Common pitfall: Stopping treatment when symptoms resolve (typically within several days) rather than completing the full 2-week course leads to high relapse rates 3

Esophageal Candidiasis

• Fluconazole 100 mg daily can be used after a 200 mg loading dose on day 1 3
• However, doses of 200-400 mg daily are more commonly recommended for esophageal disease 1
• Treat for minimum 3 weeks and at least 2 weeks following symptom resolution 3

Urinary Tract Infections

• For symptomatic Candida cystitis, fluconazole 200 mg (3 mg/kg) daily for 14 days is the standard dose 1
• The 100mg tablet would require two tablets daily for this indication 1

Chronic Suppressive Therapy

• For patients with recurrent oropharyngeal candidiasis requiring suppression, fluconazole 100 mg three times weekly is recommended 1, 2
• This is particularly relevant for HIV-infected patients, though antiretroviral therapy is the primary intervention to reduce recurrence 1, 2

Vaginal Candidiasis

• A single 150 mg dose is standard for uncomplicated vaginal candidiasis 3, 4, 5
• The 100mg tablet is not the appropriate strength for this indication 3

Key Dosing Principles

• Fluconazole exhibits dose-linear pharmacokinetics with excellent oral bioavailability (>90%), allowing once-daily dosing 6, 7
• The long half-life (31-37 hours) supports once-daily administration 6, 7
• A loading dose of twice the daily maintenance dose on day 1 achieves steady-state concentrations more rapidly 3
• Oral and intravenous doses are equivalent due to complete absorption 3

Renal Dosing Adjustment

• Dosage reduction is required for creatinine clearance <50 mL/min 7
• Fluconazole is primarily eliminated unchanged in urine (60% in 48 hours) 6

Special Populations

• For pediatric patients, 3 mg/kg is approximately equivalent to the adult 100 mg dose 3
• In neonates, particularly premature infants, dosing intervals must be extended due to prolonged half-life 3