Treatment of Peritonsillar Abscess
The treatment of peritonsillar abscess requires drainage (needle aspiration or incision and drainage), antibiotics targeting group A streptococcus and anaerobes (preferably penicillin G plus metronidazole), and supportive care with hydration and pain control, with most patients managed successfully in the outpatient setting. 1, 2
Immediate Management Approach
Drainage Procedures
- Abscess drainage is essential and should be performed via needle aspiration or incision and drainage 2
- Needle aspiration is the preferred initial drainage method for peritonsillar abscess and can be performed in the outpatient setting 3
- Internal incision is the most common surgical approach, though tonsillectomy may be performed concurrently in select cases 4
Antibiotic Therapy
- First-line antibiotic therapy should be penicillin G plus metronidazole, which provides coverage against group A streptococcus and oral anaerobes 1, 4, 2
- This regimen is superior to cefuroxime-based therapy, as cefuroxime-treated patients had longer hospitalizations (4.5 vs 3.0 days), more complications (50% vs 18%), and higher rates of abscess recurrence requiring re-operation (44% vs 3%) 4
- For patients with risk factors for complications (high CRP, prior antibiotic use, severe presentation), consider broader coverage such as piperacillin-tazobactam 4
Supportive Care
- Ensure adequate hydration, as patients often have difficulty swallowing 2
- Provide aggressive pain control to facilitate oral intake 2
- Corticosteroids should be considered as they reduce symptoms and speed recovery 3, 2
Monitoring and Complications
Warning Signs Requiring Escalation
- Monitor closely for airway obstruction, aspiration, or extension into deep neck tissues 1, 2
- Patients with systemic toxicity, severe symptoms, drooling, or neck swelling should be considered for inpatient management 1, 5
- Males and patients over 40 years are at higher risk for complications (overall mortality 10% in complicated cases) 6
Common Complications to Watch For
- Descending mediastinitis, parapharyngeal/retropharyngeal abscess extension, necrotizing fasciitis, and Lemierre's syndrome are the most serious complications 6
- Complications can develop despite appropriate antibiotic therapy and drainage 6
Definitive Management Considerations
Tonsillectomy Indications
- Patients with more than one peritonsillar abscess should be considered for tonsillectomy as definitive treatment 7, 1, 5
- The guideline threshold changed from "history of peritonsillar abscess" to ">1 peritonsillar abscess" as a modifying factor favoring tonsillectomy 7
- Immediate tonsillectomy at the time of abscess presentation has a limited but useful role in select cases 3
Outpatient vs Inpatient Decision-Making
Outpatient Management Criteria
- Most patients can be managed successfully in the outpatient setting with drainage, antibiotics, steroids, and pain control 8, 2
- An outpatient medical protocol (without drainage) showed 95.9% success rate, though this approach is less established 8