Does Acetazolamide (Diamox) cause osteopenia?

From the Research

Acetazolamide and Osteopenia

• There is limited research directly addressing the relationship between Acetazolamide (Diamox) and osteopenia.
• A study published in 2022 1 investigated the effect of acetazolamide on simulated high altitude-induced bone loss in mice. The results showed that exposure to hypobaric hypoxia significantly decreased femoral cortical thickness, but treatment with acetazolamide did not have any negative skeletal effects. However, it could not mitigate the altitude-induced bone loss.
• Other studies have focused on the various uses and side effects of acetazolamide, including its diuretic effects 2, antiepileptic properties 3, off-label uses 4, and side effect profile 5.
• None of the provided studies directly address the question of whether acetazolamide causes osteopenia in humans.

Relevant Findings

• The study on simulated high altitude-induced bone loss 1 suggests that acetazolamide may not have a negative impact on bone health, but it does not provide conclusive evidence on its effects on osteopenia.
• The lack of direct research on the topic means that no definitive answer can be provided based on the available evidence.