From the Research
Nasal sprays containing anticholinergic agents, particularly ipratropium bromide, and sympathomimetic decongestants like oxymetazoline and phenylephrine, can potentially cause urinary retention as a side effect, especially in men with enlarged prostates. The risk of urinary retention is higher in elderly patients, those with pre-existing urinary problems, benign prostatic hyperplasia (BPH), or when using multiple medications with anticholinergic properties 1. Some key points to consider:
- Anticholinergics block muscarinic receptors that normally help the bladder contract, while decongestants can increase urethral resistance through alpha-adrenergic stimulation.
- The use of concomitant medication can reinforce the impairing effect on micturition, leading to urinary retention 1.
- Alternative nasal sprays like saline solutions or steroid-based sprays (fluticasone, mometasone) are less likely to cause urinary retention and may be better options for people with urinary concerns.
- If you experience difficulty urinating after using these nasal sprays, you should contact your healthcare provider. It's essential to note that the provided studies do not directly address the question of which nasal sprays cause urinary retention, but the study by 1 provides valuable information on drug-induced urinary retention, which can be applied to this context.