From the Guidelines
Tantum mouthwash is a benzydamine hydrochloride-based solution, recommended for preventing oral mucositis in patients with head and neck cancer receiving moderate dose radiation therapy (up to 50 Gy), without concomitant chemotherapy, as stated in the ESMO clinical practice guidelines 1.
Key Characteristics of Tantum Mouthwash
- Contains benzydamine hydrochloride, an anti-inflammatory medication
- Helps reduce pain and swelling in the mouth and throat
- Effective for treating mouth ulcers, sore throats, and inflammation caused by dental procedures or radiation therapy
Usage Instructions
- Rinse with 15ml (about one tablespoon) for 30 seconds, 2-3 times daily
- Can be used undiluted or diluted with water if found too strong
- Avoid eating or drinking for at least 30 minutes after use to maximize effectiveness
Mechanism of Action
- Benzydamine works by blocking prostaglandin production, which reduces inflammation and provides local anesthetic effects
Potential Side Effects
- Temporary numbness, tingling, or a bitter taste may occur in some individuals
- If persistent mouth pain or sores last more than a week, consult a healthcare provider as this could indicate a more serious condition requiring different treatment
Recommendation
- The use of benzydamine mouthwash is recommended for the prevention of oral mucositis in patients with head and neck cancer receiving moderate dose radiation therapy, as supported by the ESMO clinical practice guidelines 1.
From the FDA Drug Label
DIRECTIONS: • Adults and children 5 to 10 drops orally, 3 times daily or as otherwise directed by a health care professional. WARNINGS: Sore throat warning: Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious.
The FDA drug label does not answer the question.
From the Research
Definition and Properties of Tantum (Benzydamine) Mouthwash
- Tantum (Benzydamine) mouthwash is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic, and local anesthetic activity 2.
- It is an indazole derivative with combined local anesthetic and analgesic properties, and antiseptic activity 3.
- Benzydamine is marketed under the brand name "Tantum Verde" 3.
Clinical Applications of Tantum (Benzydamine) Mouthwash
- Benzydamine is indicated in the relief of pain and irritation of the mouth and throat 3.
- It is used in the treatment of symptoms of irritation/inflammation of the oropharyngeal cavity, including those associated with pain 4.
- Current recognized indications of benzydamine include: relief of symptoms associated with inflammatory conditions of the mouth and oropharynx, symptomatic treatment of gingivitis and stomatitis, oral mucositis induced by chemotherapy and/or radiotherapy, and post-operative sore throat 4.
- Benzydamine has been found to be effective in the management of burning mouth syndrome (BMS) 5 and minor aphthous ulcers 6.