Does trazodone come in 100mg pills?

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Trazodone 100mg Tablet Availability

Yes, trazodone is available as 100mg tablets. 1

Available Formulations

According to the FDA drug label, trazodone hydrochloride tablets for oral administration are manufactured in the following strengths: 1

  • 50 mg tablets
  • 100 mg tablets
  • 150 mg tablets
  • 300 mg tablets

Clinical Dosing Context

The 100mg formulation is commonly used in clinical practice across different indications:

For Insomnia/Sleep Disorders

  • Initial dosing typically starts at 25-50 mg for sleep-related complaints 2, 3
  • The 100mg tablet can be used as patients titrate upward from lower starting doses 4
  • Studies demonstrate that 50-100 mg daily improves sleep disorders, with the 100 mg dosage showing particular efficacy 4

For Depression

  • Therapeutic antidepressant doses range from 150-400 mg daily 5, 6
  • The 100mg tablet allows flexible dosing as part of this therapeutic range 1
  • Maximum tolerated doses are 300-400 mg/day in elderly patients, though younger patients may tolerate up to 600 mg/day 7

Dosing Flexibility

  • The availability of 100mg tablets facilitates dose titration, as dosage increases should use increments of the initial dose every 5-7 days until therapeutic benefits become apparent 2
  • Single nighttime dosing is preferred, with 150 mg given predominantly at bedtime and increased as needed to 200-300 mg for full antidepressant efficacy 5

References

Guideline

Trazodone Dosing and Administration

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Trazodone Therapy

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Trazodone dosing regimen: experience with single daily administration.

The Journal of clinical psychiatry, 1990

Research

Antidepressant properties of trazodone.

Clinical pharmacy, 1982

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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