Brand Name for Sitagliptin Phosphate 100 MG Tablet
Sitagliptin phosphate 100 mg tablet is marketed under the brand name Januvia.
Alternative Names and Classification
- Generic name: Sitagliptin phosphate 1
- Brand name: Januvia 2, 3
- Other international brand names: Glactiv, Tesavel 4
- Drug class: DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor) 1
Key Medication Information
Standard Dosing
- Standard dose: 100 mg once daily for patients with normal renal function (eGFR >50 mL/min/1.73 m²) 5, 2
- Moderate renal impairment (eGFR 30-50 mL/min/1.73 m²): 50 mg daily 5
- Severe renal impairment (eGFR <30 mL/min/1.73 m²): 25 mg daily 5, 2
Clinical Use
- Approved indications: Used as monotherapy or in combination with metformin, thiazolidinediones, sulfonylureas, or insulin for type 2 diabetes management 2, 4
- Administration: Once daily dosing without need for titration or home blood glucose monitoring 3
- Mechanism: Inhibits DPP-4 enzyme, increasing incretin hormone levels (GLP-1), which stimulates insulin secretion and inhibits glucagon production in a glucose-dependent manner 2, 6
Important Safety Considerations
- Hypoglycemia risk: Low when used alone, but increases approximately 50% when combined with sulfonylureas 7
- Weight effect: Weight-neutral 7, 4
- Cardiovascular safety: Neutral effect on cardiovascular outcomes (TECOS trial) 7
- Renal monitoring: Requires assessment of renal function before initiation and periodically thereafter to adjust dosing 5