Boyke Classification of Penile Granuloma
I cannot provide treatment recommendations based on the "Boyke classification" for penile granuloma because this classification system does not appear in any of the provided medical literature or established clinical guidelines.
What the Evidence Actually Addresses
The provided guidelines focus exclusively on penile cancer (squamous cell carcinoma) staging and treatment, not benign granulomatous conditions 1. The research evidence describes specific types of penile granulomas but does not reference any "Boyke classification" system 2, 3, 4, 5, 6.
Actual Penile Granuloma Entities in the Literature
The research identifies several distinct granulomatous penile conditions:
Foreign body granulomas from topical cream application or paraffin/mineral oil injections (paraffinoma), which require complete surgical excision and appropriate penoplasty 2, 6
Granuloma annulare (subcutaneous variant), a benign inflammatory disorder presenting as dermal nodules, which may be managed with surgical excision or circumcision in some cases 3, 4
Xanthogranulomatous granuloma of the corpus cavernosum, a rare destructive condition that may require total penectomy in severe cases 5
Critical Clinical Distinction
If you are asking about penile lesions that might be malignant rather than benign granulomas, the NCCN guidelines provide clear staging-based treatment algorithms for penile cancer that include topical therapy, laser therapy, wide local excision, circumcision, or penectomy depending on tumor stage and grade 1.
The most important first step is obtaining histologic diagnosis through punch, excisional, or incisional biopsy to distinguish between benign granulomatous conditions and malignant lesions 1.