From the Guidelines
Sialic acid supplements should be approached with caution due to potential risks, including digestive issues, immune system effects, and interactions with certain medications, as evidenced by the lack of comprehensive clinical research on their long-term safety profile 1. The potential risks associated with N-acetylneuraminic acid (sialic acid) supplementation are multifaceted and warrant careful consideration.
- Digestive issues, such as nausea, diarrhea, and stomach discomfort, may arise in some individuals taking these supplements.
- The role of sialic acid in cell recognition processes raises concerns about possible immune system effects, particularly for people with autoimmune conditions.
- The long-term safety profile of sialic acid supplements remains largely unknown due to limited clinical research, which is a significant concern.
- Potential interactions with certain medications, such as immunosuppressants or those affecting neurological function, should be carefully evaluated.
- The quality and purity of supplements can vary widely across manufacturers, introducing the risk of contaminants. Given these considerations, if sialic acid supplementation is being considered, it is advisable to start with a low dose (typically 50-100mg daily) and monitor for adverse reactions.
- Consulting with a healthcare provider before starting supplementation is strongly recommended, especially for pregnant women, nursing mothers, children, and those with existing health conditions.
- It is also important to note that the body naturally produces sialic acid, and it is found in foods like eggs and dairy products, which may be safer sources than supplements 1. The current evidence base, including studies on human milk oligosaccharides and their impact on cognition and behavior 1, does not provide sufficient grounds to recommend sialic acid supplementation without caution.
- Further research is needed to fully understand the potential benefits and risks of sialic acid supplements, particularly in the context of human health and disease prevention.
From the FDA Drug Label
Do not use - if you are diabetic or have poor blood circulation - on irritated skin or any area that is infected or reddened - on moles, birthmarks, hairy warts, genital warts, or warts on the face or mucous membranes The risks associated with N-acetylneuraminic acid (sialic acid) supplementation are not directly stated in the provided drug label. However, the label does provide contractions and warnings for its use, including:
- Diabetes: do not use if diabetic
- Poor blood circulation: do not use if you have poor blood circulation These warnings imply potential risks, but the label does not explicitly state the risks associated with supplementation 2.
From the Research
Risks Associated with N-acetylneuraminic acid (Sialic Acid) Supplementation
- There is limited direct evidence on the risks associated with sialic acid supplementation, as most studies focus on its potential benefits or biological functions 3, 4, 5, 6.
- However, it is known that elevated sialic acid concentrations in plasma and serum have been correlated with the presence of cardiovascular diseases, diabetes, and cancer 5.
- Additionally, the use of dietary supplements, including those containing sialic acid, can be associated with risks such as adulteration with banned substances, particularly when sold illegally 7.
- The literature also suggests that taking supplements, including those containing vitamins and minerals, by healthy people does not necessarily lower their risk of chronic diseases, and their use should be recommended and monitored by a physician 7.
- There is no direct evidence on the specific risks associated with sialic acid supplementation, and more research is needed to fully understand its potential effects on human health.