Why is Dl-methylephedrine (dl-methylephedrine) a controlled substance in the United States?

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Last updated: March 28, 2025View editorial policy

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From the Research

Dl-methylephedrine is a controlled substance in the United States due to its high potential for abuse and dependence, as evidenced by its classification as a Schedule II controlled substance by the United States Drug Enforcement Administration 1. The primary reason for this classification is the substance's potential to serve as a precursor for the synthesis of other controlled substances, such as methamphetamine. Key points to consider include:

  • The potential for abuse and dependence associated with dl-methylephedrine is a major concern, leading to its controlled status in the US.
  • The classification of dl-methylephedrine as a Schedule II controlled substance implies that it has accepted medical uses, but also a high potential for abuse and dependence.
  • The use of dl-methylephedrine without proper medical supervision and authorization can lead to serious health consequences, including ischemic stroke, as reported in a case study 2.
  • It is essential to prioritize the potential risks associated with dl-methylephedrine, including its potential for abuse and dependence, when considering its use or distribution.
  • The most recent and highest quality study available, although not directly addressing dl-methylephedrine, highlights the importance of careful consideration and regulation of controlled substances due to their potential for abuse and dependence 1.

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